COPD阳气虚衰证和气阴两虚证患者细胞因子浓度的研究

目的研究慢性阻塞性肺病(COPD)阳气虚衰证和气阴两虚证患者TNF-α、IL-8、IL-1β的浓度并比较其差异。方法分别检测30例COPD阳气虚衰证患者、30例COPD气阴两虚证患者和30例健康对照者血清中TNF-α、IL-8、IL-1β的浓度。结果 COPD阳气虚衰证和气阴两虚证患者血清TNF-α、IL-8、IL-1β的浓度均高于健康对照组,差异有显著统计学意义(P<0.01),且阳气虚衰组高于气阴两虚组,差异有统计学意义(P<0.05)。结论与气阴两虚证患者相比,阳气虚衰证患者气道炎症反应更明显;通过扶阳固本延缓气阴两虚证向阳气虚衰证发展的治法,能减轻患者炎症反应带来的病理损伤。

Study on cytokine concentration in COPD Patients with Yang and Qi deficiency syndrome and Qi and Yin deficiency syndrome

Objective To study the concentration of TNF-α, IL-8 and IL-1β in patients with chronic obstructive pulmonary diseases （COPD） accompanying with Yang and Qi deficiency syn- drome and Qi and Yin deficiency syndrome, and compare the differences between them. Methods The concentration of TNF-α, IL-8 and IL-1β in COPD patients was detected respectively among 30 cases with Yang and Qi deficiency syndrome, 30 cases with Qi and Yin deficiency syndrome and 30 healthy people who were selected as the control group. Results The cytokine concentration in patients with Yang and Qi deficiency syndrome and Qi and Yin deficiency syndrome was higher than that of the controls, the differences were statistically significant （P〈0.01）; data of Yang and Qi deficiency syndrome group were higher than those of Qi and Yin deficiency syndrome group, the differences were statistically significant（P〈0.05）. Conclusion Compared with patients with Qi and Yin deficiency, the airway inflammation of patients with Yang and Qi deficiency syndrome was more obvious. The method of reinforcing Yang and strengthening body to delay the development from Qi and Yin deficiency syndrome to Yang and Qi deficiency syndrome can reduce pathologi- cal damages caused by the inflammation.