肠安I号及安慰剂对腹泻型肠易激综合征大鼠免疫功能的影响

目的：探讨肠安I号及含有低浓度肠安I号成分的安慰剂对腹泻型肠易激综合征大鼠胸腺、脾脏指数的影响。方法：采用番泻叶灌胃＋传统束缚应激剌激复制腹泻型IBS大鼠模型。中药用中药煎剂，得舒特溶液对照药物，治疗结束后，测定大鼠的胸腺、脾脏指数的含量。结果：肠安I号高、中、低剂量组体重、胸腺、脾脏指数变化与模型组比较性差异有显著（P〈0．05），其组间比较没有显著性意义；然而含5％、含10％肠安I号组经过治疗，以上指标与模型组比较没有统计学意义（P〉0．05）。结论：肠安I号高、中、低剂量可通过增加大鼠的体重、胸腺、脾脏指数，提高大鼠的免疫功能，从而发挥对IBS的治疗作用；而含5％、含10％肠安I号加辅料组没有药理作用，从而从中药的色、味方面模拟了肠安I号的特点，起到了安慰剂对照作用。

Influence on the Immune Function of Diarrhea-predominant Irritable Bowel Syndrome in Rats Treated with Chang' an Ⅰ

Objective To investigate the influence on thymus index and spleen index of diarrhea-predominant irritable bowel syndrome（IBS） in rats treated with Chang＇an I and the placebo containing low concentration Chang＇an I. Methods Senna leaf＋ traditional restraint stress were used to replicate the model of diarrhea-predominant IBS in rats. Traditional Chinese medicine was used in decoction, Pinaverium bromide was used as control drug. After the treatment, thymus index and spleen index of rats were determined. Results Compared with those of model group, body weight, thymus and spleen index changes of high, medium and low-dose group of Chang＇an I were significantly different （P 〈 0.05）, the comparison between any two groups had no significant difference; but after treatment, compared with those of model group, the above indicators of containing 5% and containing 10% Chang＇an I group had no statistical significance （P 〉 0.05）. Conolusion Chang＇an I high, medium and low doses in rats by increasing body weight, thymus and spleen index, improving the immune function of rats, which played the therapeutic effects of IBS; while containing 5% or containing 10 % Chang＇an I plus excipien group had not pharmacological effects, but had the color and taste of traditional Chinese medicine in simulating characteristics of Chang＇an I, thus played a role in placebo-controlled trial.