Fasting and ketogenic diet effects on audiogenic seizures susceptibility of magnesium deficient rats |
| |
Authors: | A W Mahoney D G Hendricks N Bernhard D V Sisson |
| |
Affiliation: | 1. Department of Nutrition and Food Sciences UMC 87, Colleges of Family Life and Agriculture Utah State University, Logan, UT 84322, USA;3. Department of Statitics, Utah State University, Logan UT 84322, USA |
| |
Abstract: | Because fasting and ketogenic diets decrease seizure susceptibility in epileptics, their anticonvulsant effects were studied using sound-induced seizures in the magnesium-deficient rat. Fasting markedly depressed seizure incidence and severity but did not affect latency (sec to seizure onset). High-fat diet increased incidence of audiogenic seizures and seizure severity, and decreased latency. Gavage of medium chain triglyceride, beta-hydroxybutyrate or glucose did not affect seizure incidence, seizure severity or latency. Nonspecific excitability level was not associated with treatment nor with seizure incidence, severity or latency time. |
| |
Keywords: | Ketogenic diet Epileptics Audiogenic seizure susceptibility Magnesium deficient diet Rats Fasting |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|