三阴乳腺癌术后患者血脂水平与其3年预后的关系

目的 探讨三阴乳腺癌术后患者血脂水平与其3年预后情况的相关性。方法 通过收集并随访122例三阴乳腺癌术后患者相关临床资料，依据患者术后3年内疾病有无进展分为2组，分别为进展组（n=40），未进展组（n=82），比较两组患者一般临床资料及术后血脂水平差异；定量数据采用t检验，定性数据采用χ²检验，采用Logistic回归分析找出疾病进展的危险因素及独立危险因素。结果 三阴乳腺癌术后患者3年疾病进展组胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）均显著高于未进展组（P<0.05），进展组患者高密度脂蛋白胆固醇（HDL-C）显著低于未进展组（P<0.05）；高TC血症、高TG血症、高LDL-C血症、肿块直径、淋巴结分期、组织学分级为三阴乳腺癌患者术后3年疾病进展的危险因素，其中高TC血症、高TG血症、淋巴结分期为独立危险因素。结论 血脂水平与三阴乳腺癌预后密切相关，需有效监测患者血脂水平，并应采取措施及时干预血脂水平异常。

Association of Serum Lipid and 3-year Prognosis Situation in Patients with Triple-negative Breast Cancer after Surgery

Objective To investigate the connection between the serum lipid level of a patient with triple-negative breast cancer after the operation and the prognosis situation three years after the operation. Methods By collecting and following up the related clinical information of 122 patients with triple-negative breast cancer who have undergone the operation, we divided these patients into two groups including the group with progress (n=40) and the group without progress (n=82) according to the fact that whether there is any progress of the disease. Then we compare the general clinical information as well as the lipid level difference of the two groups. A t-test was used for the quantitative data while chi-square was used for qualitative data. We then used the Logistic regression analysis to find out the risk factors as well as the independent risk factors of the disease progression. Results Three years after the operation, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) of patients in the group with progress were all obviously higher those of patients in the group without progress (P<0.05) while high-density lipoprotein cholesterol (HDL-C) of patients in the group with progress is obviously lower than that of patients in the group without progress(P<0.05). The risk factors of the disease progress of patients with triple-negative breast cancer three years after the operation were higher serum levels of TC, higher serum levels of TG, higher serum levels of LDL-C, the tumor size, lymph node staging and histological grade, among which higher serum levels of TC, higher serum levels of TG and lymph node staging were the independent risk factors. Conclusion Since the lipid level is closely related to the prognosis of triple-negative breast cancer, we shall effectively monitor the lipid level of the patients and take measures to intervene dyslipidemia in time.