子宫肌瘤腹腔镜剥除术中止血药物效果分析

目的 探讨垂体后叶素与缩宫素在腹腔镜下肌壁间子宫肌瘤剥除术的临床效果。方法 选取2015年10月~2016年12月行腹腔镜下子宫肌瘤剥除术的患者60例，分成两组各30例。治疗组注射6IU垂体后叶素+10ml生理盐水，对照组注射20U缩宫素+10ml生理盐水，按照两组的用药情况，观察比较血压变化和其他情况。结果 治疗组与对照组比较，手术时间明显减少（98.13±5.07min vs 110.83±8.03min，t=-7.324，P=0.000），术中出血量明显减少（67.50±10.24ml vs 97.83±16.10ml，t=-8.705，P=0.000），血红蛋白术前术后变化（9.67±2.09g/L vs 11.53±2.21g/L，t=-3.362，P=0.001）。术中用药后15min，治疗组收缩压上升，显著高于对照组（150.77±5.57mmHg vs 142.03±5.21mmHg，t=6.273，P=0.000）。结论 腹腔镜下肌壁间子宫肌瘤剥除术应用垂体后叶素止血效果明显优于缩宫素，但会引起短暂性血压升高，临床使用应结合患者病情个性化选择。

Effect of Hemostatic Drug in Laparoscopic Enucleation of Hysteromyoma

Objective To explore the clinical effect of pituitrin and oxytocin in laparoscopy myomectomy of intramural fibroids. Methods Sixty patients received laparoscopy myomectomy of intramural fibroids during October 2015-December 2016 were selected and divided into two groups with 30 cases in each. We applied injections of pituitrin 6IU+10ml normal saline to treatment group while 20U oxytocin+10ml normal saline to control group so as to compare their blood pressure change and other situations based on medication. Results Compared with control group, the time of operation and amount of bleeding during operation in treatment group reduced obviously(98.13±5.07min vs 110.83±8.03min,t=-7.324,P=0.000).The hemoglobin changed before and after operation(67.50±10.24ml vs 97.83±16.10ml,t=-8.705,P=0.000). 15min after medication during operation, the systolic pressure in treatment group increased obviously, which was higher than that in control group(150.77±5.57mmHg vs 142.03±5.21mmHg,t=6.273,P=0.000). Conclusion The application of pituitrin to laparoscopy myomectomy of intramural fibroids was better hemostatic effect than oxytocin, but it may generate temporary elevation of blood pressure, so the clinical application should combine with patients'' individual situation.