内镜下止血联合奥曲肽对急性上消化道出血患者的血流动力学及临床疗效的影响

目的 探究内镜下止血联合奥曲肽对急性上消化道出血患者的血流动力学及临床疗效的影响。方法 纳入2019年1月至2022年6月江西省新余银河医院急性上消化道出血患者80例，随机分为对照组和观察组，每组40例。对照组采用常规内镜治疗，观察组在对照组基础上联用奥曲肽。比较两组患者临床疗效、治疗前后高敏C反应蛋白（high sensitivity C-reactive protein, hs-CRP）、皮质醇（cortisol, Cor）水平及血流动力学变化心输出量（cardiac output,CO）、心率（heart rate,HR）、平均动脉压（mean arterial pressure, MAP）]。结果 观察组患者总有效率更高（P<0.05）。治疗后，两组患者hs-CRP、Cor水平均降低，且观察组低于对照组（P<0.05）。治疗后，两组患者CO、HR及MAP水平均降低，且观察组低于对照组（P<0.05）。结论 内镜下止血联合奥曲肽可促进急性上消化道出血患者血流动力学指标恢复正常，改善患者的hs-CRP、Cor水平，提高临床疗效。

Effect of endoscopic hemostasis combined with octreotide on hemodynamics and clinical outcome of patients with acute upper gastrointestinal bleeding

Objective To explore the effect of endoscopic hemostasis combined with octreotide on hemodynamics and clinical outcome of patients with acute upper gastrointestinal bleeding. Methods From January 2019 to June 2022, 80 patients with acute upper gastrointestinal bleeding in Xinyu Yinhe Hospital of Jiangxi Province, and according to random number table method, 40 cases each in the control group and 40 cases in the observation group. The control group was treated with conventional endoscopic, while the observation group was treated with octreotide on this basis. The clinical efficacy, high sensitivity C-reactive protein (hs-CRP), cortisol (Cor) levels and hemodynamic changes cardiac output (CO), heart rate (HR), mean arterial pressure (MAP)] were compared between the two groups. Results The total effective rate of the observation group was significantly higher (P<0.05). After treatment, hs-CRP and Cor levels in 2 groups were lower than before, and hs-CRP and Cor levels in observation group were significantly lower (P<0.05). After treatment, the levels of CO, HR and MAP in the two groups were decreased, and the levels of CO, HR and MAP in the observation group were significantly lower (P<0.05). Conclusion Endoscopic hemostasis combined with octreotide can promote the hemodynamic indexes of patients with acute upper gastrointestinal bleeding to return to normal, improve the levels of hs-CRP and Cor, and improve clinical efficacy.