基于文献计量学和专利分析的板蓝根研究现状剖析及产业化前景展望

目的 系统梳理板蓝根研究现状及发展趋势，为板蓝根资源的高值化利用提供策略。方法 通过收集近年来中国学术期刊全文数据库（CNKI）以及Web of Science（WOS）核心合集数据库中涉及板蓝根的文献数据集，利用CiteSpace进行文献计量学分析并可视化。通过国家知识产权局专利检索及分析系统检索板蓝根相关专利申请情况，从专利申请趋势，申请人技术主题等方面分析板蓝根资源开发利用现状。结果 我国板蓝根产业已经初步形成，涉及面较广。当前，以多糖、表告依春、靛玉红等为主要活性成分的研究；以抗炎、抗病毒、抗内毒素等为主的药理作用研究；以组合药物制剂开发为主要药物开发形式是当前板蓝根主要的研究和应用方向。但仍存在板蓝根质量难控制、资源利用效率低、科技含量不足等制约板蓝根产业健康发展的因素。结论 板蓝根在中医药领域中有着重要的地位，我国板蓝根产业化发展仍需进一步加强。通过不断加强科技创新和产业链协同，有望提升我国板蓝根产业的竞争力。

Analysis of research status and industrialization prospect of Isatidis Radix based on bibliometrics and patents

Objective To systematically sort out the current status and development trend of the research on Banlangen (Isatidis Radix), and provide strategies for the high-value utilization of Isatidis Radix resources. Methods By collecting the literature data involving Isatidis Radix in the Chinese Academic Journals Full Text Database (CNKI) and Web of Science (WOS) Core Collection Database in recent years, bibliometric analysis and visualization were performed using CiteSpace. At the same time, the patent applications related to Isatidis Radix were searched through the patent search and analysis system of the State Intellectual Property Office, and the current status of Isatidis Radix resources development and utilization was analyzed in terms of the trend of patent applications and the applicant''s technological themes. Results The Isatidis Radix industry in China has initially taken shape and covers a wide range. Currently, research on active ingredients such as polysaccharides, epigoitrin, and indirubin; Research on pharmacological effects mainly focused on anti-inflammatory, antiviral, and anti-endotoxin effects; The main research and application direction of Isatidis Radix is to develop combination drug preparations as the main form of drug development. However, there are still factors that hinder the healthy development of the Isatidis Radix industry, such as difficulty in controlling the quality of Isatidis Radix, low resource utilization efficiency, and insufficient technological content. Conclusion Isatidis Radix plays an important role in the field of traditional Chinese medicine, and the industrialization development of Isatidis Radix in China still needs to be further strengthened. By continuously strengthening technological innovation and industrial chain collaboration, it is expected to enhance the competitiveness of Isatidis Radix industry.