痰湿证PCOS患者伴高雄激素血症268例分析

目的 通过比较不同水平雄激素状态下痰湿证PCOS患者的临床及生化特征，探索出痰湿证PCOS伴HA患者的临床特征，为疾病的个性化治疗和远期并发症的预防提供依据。方法 收集2014年12月~2017年8月黑龙江中医药大学附属第一医院临床科研信息一体化系统中436例痰湿证PCOS患者，分为高雄组268例及非高雄组168例，对照组83例，分析并比较3组的临床特征及生化指标。结果 痰湿证PCOS+HA组的多毛、黑棘皮及溢脂发生率显著高于痰湿证PCOS+non-HA组（P<0.05）；与痰湿证PCOS+non-HA组相比，痰湿证PCOS+HA组的FSH及SHBG显著降低、LH及LH/FSH显著升高，差异有统计学意义（P<0.05）；痰湿证PCOS+HA组的TC、TG、LDL值显著高于痰湿证PCOS+non-HA组和对照组（P<0.05）；痰湿证PCOS+HA组的FPG、FINS、HOMA-IR值均显著高于痰湿证PCOS+non-HA组及对照组（P<0.05）。结论 痰湿证PCOS合并HA患者多毛、黑棘皮及溢脂发生率较高；痰湿证PCOS合并HA患者性激素代谢异常较重；痰湿证PCOS合并HA患者糖脂代谢紊乱较重。

Anaysis of 268 Cases of Phlegm-dampness Syndrome of PCOS with Hyperandrogenism

Objective Through the collection and analysis of clinical features and biochemical indices data got from 436 women who were diagnosed as phlegm-dampness syndrome of PCOS, in order to provide the reference for the personalized treatment for disease and prevention of long-term complication.Methods We collected 436 cases of patients diagnosed with phlegm-dampness syndrome of PCOS and 62 cases of control group from December 2014 to August 2017. We analysied and compared of three groups of clinical and biochemical indicators.Results The incidence of hirsutism,acanthosis nigricans and excessive fat of phlegm-dampness syndrome of PCOS+HA subgroup were higher than phlegm-dampness syndrome of PCOS+non-HA subgroup(P<0.05). The LH and LH/FSH of of phlegm-dampness syndrome of PCOS+HA subgroup were higher.The level of FSH and SHBG was lower than phlegm-dampness syndrome of PCOS+non-HA subgroup and the control group(P<0.05). The TC, TG and LDL of phlegm-dampness syndrome of PCOS+HA subgroup were higher than phlegm-dampness syndrome of PCOS+non-HA subgroup and the control group(P<0.05).The FPG, FINS and HOMA-IR of phlegm-dampness syndrome of PCOS+HA subgroup is higher than phlegm-dampness syndrome of PCOS+non-HA subgroup and the control group(P<0.05).Conclusion The patients with phlegm-dampness syndrome of PCOS+HA have higher incidence of hirsutism,acanthosis nigricans and excessive fat.The patients with phlegm-dampness syndrome of PCOS+HA have serious sex hormone metabolic disorders.The patients with phlegm-dampness syndrome of PCOS+HA have serious glucolipid metabolic disorders.