急性胰腺炎患者血清新喋呤水平变化及意义

目的: 探讨急性胰腺炎患者新喋呤变化规律及临床意义。方法: 28例胰腺炎患者依据严重程度分为轻型组、重症组,测定发病当天及第4天、第8天、第14天患者血清新喋呤含量,记录APACHE Ⅱ评分,分析新喋呤水平与急性胰腺炎严重度关系。结果: 重症胰腺炎发病第8天和第14天新喋呤水平均高于轻型组(P<0.01和P<0.001),其值与APACHE Ⅱ评分呈正相关(P<0.05)。重症急性胰腺炎病死组发病第8天和第14天新喋呤水平亦均高于重症急性胰腺炎存活组(P<0.05和P<0.001)。结论: 急性胰腺炎患者血清新喋呤水平升高,与疾病严重程度有一定的相关性,动态检测新喋呤水平可能有助于急性胰腺炎严重程度及预后的判断。

Significance of changes of serum neopterin for patients with acute pancreatitis

Objective: To evaluate the clinical significance of changes of serum neopterin levels in patients with acute pancreatitis.Methods: Twenty-eight patients were divided into mild group and severe group.Their blood samples were obtained at 0,4th,8th and 14th day after admission and the APACHE Ⅱ scores were recorded.Results: Severe patients showed a high neopterin levels,and the correlation between the mean neopterin levels and APACHE Ⅱ was observed at 8th day and 14th day(P<0.05 and P<0.01).In addition,the serum neopterin levels of patients with fatal outcome were much higher than those of surviving patients at 8th day and 14th day(P<0.05 and P<0.001).Conclusions: The rise of neopterin level in patients with acute pancreatitis is related to the severity of pancreatitis.Measurement of serum neopterin may help to predict the severity and prognosis of patients with acute pancreatitis.