茶儿茶素对小鼠的辐射防护作用

目的探讨儿茶素对小鼠的辐射防护作用。方法采用6MVX直线加速器一次性全身照射小鼠,儿茶素加照射组以200mg/kg.d儿茶素灌服动物10d后施行照射。比较两组小鼠体质量变化、外周血白细胞总数、平均存活时间及30d生存率。结果儿茶素加照射组小鼠体质量减轻低于照射组,平均生存时间明显长于照射组,30d存活率比对照组明显升高,而且儿茶素能加快单纯受照射小鼠外周血白细胞的恢复。结论儿茶素对受照射小鼠有明显的辐射防护作用。

Radioprotective effect of catechines against radiation injury in mice

Objective To study the radioprotective effect of catechines against radiation injury in mice.Methods Catechines were administered in mice intragastrically at the daily dose of 200 mg/kg for 10 consecutive days before whole body irradiation with 6 Gy X-rays.The body weight changes,survival time,30-day survival rate,and counts of peripheral white blood cells were recorded.Results The mice with catechine pre-treatment before X-ray exposure suffered less body weight loss than those without the treatment before exposure.Catechines markedly increased the survival time of the irradiated mice,and raised the 30-d survival rate of the irradiated mice to 53.33% as compared with the rate of 13.33% in the radiated mice without catechine pre-treatment.Catechines significantly promoted recovery of peripheral white blood cells.Conclusion Catechines have definite radioprotective effect against radiation injury in mice.