| 骨肉瘤Bcl—2蛋白表达和细胞凋亡的关系 |
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| 引用本文： | 王健,张进禄,张伟. 骨肉瘤Bcl—2蛋白表达和细胞凋亡的关系[J]. 山东医药, 2001, 41(24): 22-23 |
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| 作者姓名： | 王健 张进禄 张伟 |
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| 作者单位： | 山东省立医院, |
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| 摘 要： | 利用原位末端标记法（TUNEL）检测并观察骨肉瘤细胞中的凋亡情况及LSAB免疫组织化学方法检测Bcl－2表达和分布。结果显示凋亡细胞检测阳性率为57．14％（32／56），Bcl-2蛋白表达阳性率为28．57％（16／56），细胞凋亡与Bcl-2的表达呈显著的负相关（P＜0．05），细胞凋亡Bcl-2蛋白表达与Enneking临床分期显著相关，认为骨肉瘤细胞中存在细胞凋亡现象，细胞凋亡减少与Bcl-2的表达增加，提高了肿瘤的浸润，生长能力。
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| 关 键 词： | 细胞凋亡 Bcl－2基因 骨肉瘤 原位末端标记法 TUNEL |
| 修稿时间： | 2001-10-12 |
The relationship between apoptosis and BCL-2 expression in octeosarcoma |
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| Wang Jian,Zhang Jinlu,Zhang Wei. The relationship between apoptosis and BCL-2 expression in octeosarcoma[J]. Shandong Medical Journal, 2001, 41(24): 22-23 |
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| Authors: | Wang Jian Zhang Jinlu Zhang Wei |
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| Abstract: | To study the apoptosis,Bcl-2 expression and their biological significance in osteosatcoma,the apoptotic cells were detected by the TDT mediated dUPT-biotin nick end-labelling(TUNEL)technique.Bcl-2 on coprotein was investigated by using labelled Stteptavidin Biotin(LSAB)immunohistochemical method.Results showed that in 56 cases of osteoscom a tissues,apoptotic bodys were detected in 32(54.17%)cases;Bcl-2 proteins were expressed in 16(28.75%)cases.Bcl-2 protein-positive tate was significantly lowetet in tissued with clinical Enneking stage . than that of with clinical Enneking stage .This suggested apoptosis and telated genes-bcl-2 may play a significant tole in the course of the developmenting of osteosatcoma. |
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| Keywords: | Apoptosis Bcl-2 Osteosatcoma |
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