| HPLC测定盐酸异丙嗪糖浆中盐酸异丙嗪含量 |
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| 引用本文： | 宋霞林, 谌官和. HPLC测定盐酸异丙嗪糖浆中盐酸异丙嗪含量[J]. 中国现代应用药学, 2008, (3): 230-231. |
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| 作者姓名： | 宋霞林 谌官和 |
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| 摘 要： | 目的 建立高效液相色谱法测定盐酸异丙嗪糖浆中盐酸异丙嗪的含量.方法 以NUCLEODUR100-5C18ec(150 mm×4.6 mm,5 μm)为色谱柱,0.02 mol·L-1磷酸二氢钾缓冲盐溶液(取磷酸二氢钾2.72 g加水700 mL溶解,用磷酸调节pH=3.0,加水至1 000 mL)-乙腈-甲醇(60:17:23)为流动相,流速0.8 mL·min-1,检测波长为249 nm;柱温为30 ℃.结果 盐酸异丙嗪在5.445～98.01 μg·mL-1浓度范围内线性关系良好(r=0.999 93);方法精密度RSD=0.78%(n=6);其高、中、低三个量的平均回为99.88%,99.91%,100.2%,RSD分别为0.31%,0.21%,0.46%.结论 本方法准确、可靠,适用于盐酸异丙嗪糖浆的含量测定.
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| 关 键 词： | 高效液相色谱法 盐酸异丙嗪糖浆 盐酸异丙嗪 含量测定 |
Determination of Promethazine Hydrochloride in Promethazine Hydrochloride Syrup by HPLC |
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| SONG Xia-Lin, CHEN Guan-Huo. Determination of Promethazine Hydrochloride in Promethazine Hydrochloride Syrup by HPLC[J]. Chinese Journal of Modern Applied Pharmacy, 2008, (3): 230-231. |
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| Authors: | SONG Xia-Lin CHEN Guan-Huo |
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| Abstract: | OBJECTIVE To establish a HPLC method for determining the content of promethazine hydrochloride in promethazine hydrochloride syrup.METHODS The determination of promethazine hydrochloride in promethazine hydrochloride syrup was carried on a column of NUCLE |
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| Keywords: | HPLC promethazine hydrochloride syrup promethazine hydrochloride determination content. |
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