肺癌中瘦素受体的表达及其在血管生成中的作用

目的研究瘦素受体（OB-R）、血管内皮生长因子（VEGF）和微血管密度（MVD）在肺癌组织中的表达，探讨瘦素受体在肺癌血管生成中的作用和机制。方法免疫组化法检测40例肺癌组织和正常对照组织中OB-R、MVD、VEGF的表达。结果肺癌及正常肺组织瘦素受体的阳性表达率分别为67．50％、37．50％，两组比较差异有统计学意义（P〈0．05）。瘦素受体的表达与性别年龄，肿物大小，病理类型无关（P〉0．05），而与MVD，淋巴转移有关（P〈0．05），肺癌组织中OB—R阳性组的MVD较阴性组高。VEGF阳性组的MVD明显高于阴性组。OB—R与VEGF表达部位一致，呈正相关（P〈0．05）。结论肺癌组织中OB-R表达增多对肺癌血管成生成促进作用，并且该作用可能与VEGF的上调有关。

The expression of leptin receptor OB-R and its angiogenic effect in lung cancer

Objective To investigate the expression of leptin receptor （OB-R） in lung cancer and to explore the effect of tumor angiogenesis and possible mechanism. Methods Patients with lung cancer confirmed pathologically were included in this study. Immumohistochemical staining was performed to detect the expression of OB-R, MVD, VEGF in tumor tissues and they own normal controls. Resuits In Lung cancer and normal lung tissues, the positive rates of OB-R expression were 85.0%, 60.0% , respectively （P 〈 0. 05 ）. The OB-R expression was not related to age, sex, tumor size and pathological type, （ P 〉 0. 05 ） , but related to MVD and lymph node metastasis, （P 〈 0. 05 ）. The MVD in the OB-R positive group was higher than that in the OB-R negative group. The MVD in VEGF in the positive group was higher than that in the VEGF negative group. The expression of the OB-R and VEGF on similar location was observed, and they had positively related. Conclusion The study suggests that increased expression of OB-R contributes to tumor angiogenesis in tung cancer, probably through up-regulating the expression of VEGF.