Sarcomas and sarcomatoid tumor after radiotherapy of oral squamous cell carcinoma: analysis of 4 cases. |
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| Authors: | Ya-Wei Chen Hsi-Fen Tu Tsen-Hsian Wu Wen-Liang Lo Che-Shoa Chang Kuo-Wei Chang Shou-Yen Kao |
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| Affiliation: | Oral and Maxillofacial Surgery, Department of Dentistry, Taipei Veterans General Hospital (Taipei VGH), School of Dentistry, National Yang-Ming University, Taipei, Taiwan, ROC. |
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| Abstract: | Radiation-induced sarcoma (RIS) or postirradiation sarcoma has been reported rarely as a long-term complication of radiation therapy (RT). We report 4 cases of oral sarcomas or sarcomatoid tumors with a rather short latency period after radiotherapy of the prior OSCC. Histopathological evaluation and immunohistochemical study were performed using a panel of markers including vimentin, cytokeratin, S-100, desmin, myoglobin, HHF-35, p53, and p16. All reported cases were positive for vimentin and negative for cytokeratin. Two cases were positive for myoglobin, desmin, or HHF-35, and were probably myogenic origin. One case was possibly a fibrosarcoma and the subclassification of the other one was not specified. Diverse expression of p53 and p16 was further observed in these 4 cases. Report of the complicated clinical processes and the analysis of genetic markers of these cases provide useful clinical and pathogenetic insights of mesenchymal malignancies associated with a status post OSCC radiation. |
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