Histamine release and fibrinogen adsorption mediate acute inflammatory responses to biomaterial implants in humans |
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Authors: | Johann Zdolsek John W Eaton Liping Tang |
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Institution: | 1. Department of Hand and Plastic Surgery, University Hospital, SE-581 85, Link?ping, Sweden 2. Molecular Targets Program, Brown Cancer Center, University of Louisville, 40202, Louisville, KY, USA 3. Bioengineering Department, University of Texas at Arlington, 76019, Arlington, TX, USA
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Abstract: | Background Medical implants often fail as a result of so-called foreign body reactions during which inflammatory cells are recruited
to implant surfaces. Despite the clinical importance of this phenomenon, the mechanisms involved in these reactions to biomedical
implants in humans are not well understood. The results from animal studies suggest that both fibrinogen adsorption to the
implant surface and histamine release by local mast cells are involved in biomaterial-mediated acute inflammatory responses.
The purpose of this study was to test this hypothesis in humans. |
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Keywords: | |
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