Non-invasive assessment of motor unit activation in relation to motor neuron level and lesion location in stroke and spinal muscular atrophy |
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| Institution: | 1. Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, United States;2. Yale School of Medicine, 333 Cedar St, New Haven, CT 06510, United States;3. Spaulding Rehabilitation Hospital, 1575 Cambridge St, Cambridge, MA 02138, United States;4. Department of Medicine — General Medicine Division, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, United States;5. College of Nursing and Health Sciences, UMass Boston, 100 Morrissey Blvd., Boston, MA 02125, United States;6. Health and Disability Research Institute, Boston University School of Public Health, 715 Albany St, Boston, MA 02118, United States;7. Department of PM&R, Harvard Medical School, 300 First Avenue, Boston, MA 02129, United States;1. Department of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, TIRR Memorial Hermann Research Center, Houston, TX, United States;2. Guangdong Work Injury Rehabilitation Center, Guangzhou, China;3. Biomedical Engineering Program, University of Science and Technology of China, Hefei, China;1. Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, China;2. Department of Hand and Upper Extremity Surgery, Jing''an District Center Hospital, Fudan University, Shanghai, China;3. Department of Radiology, Jing''an District Center Hospital, Fudan University, Shanghai, China;4. Shanghai Clinical Medical Center for Limb Function Reconstruction, Shanghai, China;5. Department of Orthopaedic Surgery, Jing''an District Center Hospital, Fudan University, Shanghai, China;6. Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China;7. National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China;8. Research Unit of Synergistic Reconstruction of Upper and Lower Limbs After Brain Injury, Chinese Academy of Medical Sciences, Shanghai, China;9. The Shanghai Ninth People''s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China |
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| Abstract: | BackgroundNeuromuscular disorders e.g. spinal muscular atrophy and stroke have a negative impact on functional movement capability. These disorders affect lower and upper motor neurons respectively.MethodsIn this study high spatial resolution electromyography was used to record the motor unit activity in 3 groups: healthy subjects, a spinal muscular atrophy group and a stroke group. 7 clinically sensitive parameters were used to analyze the activation patterns of a few motor units.FindingsIn the case of spinal muscular atrophy there was no effect on motor unit activation but on their number. Stroke was characterized by fewer active motor units and a significantly reduced firing rate with low variability.InterpretationThe results suggest, that for stroke, information from the brain is modified thereby resulting in motor units firing at their natural frequency. Thus, high spatial resolution electromyography and the chosen parameters facilitate non-invasive, objective differentiation and analysis of the activation patterns of motor units in neuromuscular disorders. |
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