Spect-neuropsychology correlations in very mild Alzheimer's disease and amnesic mild cognitive impairment |
| |
| Institution: | 1. Department of Neuroscience, S. Camillo Hospital, Rome, Italy;2. Nuclear Medicine Department, Regina Apostolorum Hospital, Albano Laziale, Rome, Italy;3. Stroke Unit, Spaziani Hospital, Frosinone, Italy;4. Institute of Geriatrics and Gerontology, University of Perugia, Perugia, Italy;1. Department of Psychology, Vision Sciences and Human Biofactors Laboratories, The University of Georgia, Athens, GA, USA;2. Abbott Nutrition, Columbus, OH, USA;3. Nevada State College, Henderson, NV, USA;4. Department of Psychology, Neuropsychology and Memory Assessment Laboratory, The University of Georgia, Athens, GA, USA;1. Faculty of Health, Sports and Social Work, Inholland University of Applied Sciences, Amsterdam, the Netherlands;2. Zonnehuisgroep Amstelland, Amstelveen, the Netherlands;3. Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium;4. Department of Physiotherapy and Occupational Therapy, Aalborg University Hospital, Denmark;5. Public Health and Epidemiology Group, Department of Health, Science and Technology, Aalborg University, Denmark;1. VU Medical Center Alzheimer Center, Amsterdam, The Netherlands;2. Department of Radiology and Nuclear Medicine, VU Medical Center, Amsterdam, The Netherlands;3. Department of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany;1. Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Hamburg, Germany;2. Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Germany;1. Department of General and Experimental Psychology, Ludwig-Maximilians-Universität München, Munich, Germany;2. Graduate School of Systemic Neurosciences, LMU, Munich, Germany;3. Hans Berger Department of Neurology, Jena University Hospital, Jena, Germany;4. Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technische Universität München, Munich, Germany;5. Klinikum rechts der Isar, TUM-NIC Neuroimaging Center, Technische Universität München, Munich, Germany;6. Klinikum rechts der Isar, Department of Neuroradiology, Technische Universität München, Munich, Germany;1. School of Psychology, University of Bristol, Bristol, UK;2. Division of Psychology and Language Sciences, Faculty of Brain Sciences, University College London, London, UK;3. Department of Geriatric Medicine, Cardiff University, Cardiff, UK;4. South Glos Memory Services, Avon and Wiltshire Mental Health Partnership, Bristol, UK;5. Department of Experimental Psychology, University of Oxford, Oxford, UK;6. Department of Psychology, University of Swansea, Swansea, UK |
| |
| Abstract: | BackgroundThe purpose of this study was to explore the clinical and brain functional abnormalities in patients with mild Alzheimer’s Disease (AD) and patients with amnesic Mild Cognitive Impairment (aMCI).Methodswe used resting spect-neuropsychology correlations method.ResultsWe found that parieto-temporal associative cortex, mainly involving the inferior parietal lobule, posterior cingulate and middle temporal gyrus, is compromised early in AD. These results suggest that the dysfunction in these areas contributes to cognitive decline in the storage of verbal information, drawing abilities and non-verbal abstract reasoning in AD. The aMCI group showed hypoperfusion primarily involving the frontal areas bilaterally, and this correlated with the impairment in free delayed recall on a verbal memory task.ConclusionOur results underlie the clinical differences between AD and aMCI patients that might reflect the involvement of different degenerative mechanisms in these groups. |
| |
| Keywords: | Alzheimer disease Neuropsychology AD and MCI Memory disorders Diagnostic criteria Neuroimaging and cognitive disorders |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
