The association of age-related differences in serum total testosterone and sex hormone-binding globulin levels with the prevalence of diabetes |
| |
| Affiliation: | 1. Far Eastern Memorial Hospital, Department of Pediatrics, Taipei, Taiwan;2. Department of Health Services Administration, China Medical University, College of Public Health, Taichung, Taiwan;3. Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;4. Department of Medicine, Mackay Medical College, New Taipei City, Taiwan;5. Section of Psychiatry, Mackay Memorial Hospital, Taipei, Taiwan;6. Mackay Junior College of Medicine, Nursing and Management, Taipei, Taiwan;7. Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan;8. College of Medicine, China Medical University, Taichung, Taiwan;1. School of Medicine & Pharmacology, University of WA, Fremantle Hospital, Fremantle, Western Australia 6160;2. School of Population Health, University of WA, Western Australia 6009;3. Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009;4. School of Psychiatry & Clinical Neurosciences, University of WA, Fremantle Hospital, Fremantle, Western Australia 6160 |
| |
| Abstract: | BackgroundAge-related differences of sex hormones are traditionally considered detrimental to certain diseases particularly in middle-aged and elderly males, however, it is imprudent to conclude without elucidating the influences of other age-related pathophysiology apart from reproductive aging. We sought to examine serum testosterone and sex hormone-binding globulin (SHBG) levels from different decades of life and their associations with the prevalence of diabetes in each respective decade.Materials and methodsA total of 6296 males participated in this multicenter cross-sectional study, aged between 40–79 years. Information on diabetes and associated risk factors were obtained by questionnaires. Serum total testosterone (TT), SHBG and calculated free testosterone (fT) were determined.ResultsAge-related stable level of TT even with significantly lower level of fT did not result in a higher age-related odds of diabetes. Whereas, age-related higher SHBG level was associated with a lower age-related odds of diabetes [−5.88 % (p = 0.038), −14.28 % (p = 0.003) and −23.53 % (p = 0.001) for males aged 50–59, 60–69, 70–79 years, respectively]. Also, the combined age-related differences of TT and SHBG levels were found associated with a lower age-related odds of diabetes [−2.21 % (p = 0.040), −8.16 % (p = 0.025) and −14.37 % (p = 0.002) for males aged 50–59, 60–69, 70–79 years, respectively].ConclusionsThe differences in hormonal levels of each age group category showed a negative association with the prevalence of diabetes in middle-aged and elderly males, however, this association could be deterred in the presence of obesity. |
| |
| Keywords: | Testosterone Sex hormone-binding globulin Diabetes mellitus Age Hypogonadism Obesity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
