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Dose and time dependent cerebrovascular and metabolic effects of ethanol |
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| Authors: | W E Hoffman D J Miletich R F Albrecht |
| Affiliation: | 1. Division of Interventional Cardiology, Banner University Medical Center, Phoenix, AZ, USA;2. Division of Cardiology Mount Sinai Medical Center, Columbia University, Miami Beach, FL, USA;3. Department of Medicine, East Tennessee State University, Johnson City, TN, USA;4. Division of Cardiology, State University of New York at Buffalo, Buffalo, NY, USA;5. Department of Medicine and Therapeutics, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong Special Administrative Region;6. Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin 300211, People''s Republic of China;7. Andreas Gruentzig Cardiovascular Center, Emory University School of Medicine, Atlanta, GA, USA;8. Department of Medicine, Geisinger Commonwealth School of Medicine, Geisinger, PA, USA |
| Abstract: | The purpose of these experiments was to determine the effect of ethanol dose and time of administration on cerebral blood flow (CBF) and cerebral oxygen consumption (CMRO2). CBF and CMRO2 were measured in Sprague-Dawley rats 30 and 90 minutes after intraperitoneal injections of ethanol. Blood alcohol concentrations ranged from 1 to 3 mg/ml and were equivalent at both time periods. Ethanol produced small but significant increases in CBF and CMRO2 with blood alcohol concentrations. The above changes were not time dependent and were similar between 30 and 90 minute testing periods. The dose dependent effects of ethanol on cerebral metabolism are consistent with in vitro studies suggesting a dose related effect of ethanol on neuronal metabolism. The time of application appears to have little effect on the cerebral metabolic effects of alcohol. |
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