粘蛋白MUC2、MUC5AC在大肠腺癌中的表达及意义

目的探讨粘蛋白MUC2与MUC5AC在大肠腺癌及大肠腺瘤中的表达及其与临床病理参数之间的关系.方法应用免疫组织化学方法对20例大肠腺瘤和60例大肠腺癌进行粘蛋白MUC2、MUC5AC检测.结果20例大肠腺瘤及60例大肠腺癌中,粘蛋白MUC2阳性表达率分别为100%、58.3%(P=0.000);在大肠腺癌中MUC2的阳性表达与生存期(P=0.008)呈正相关,而与浸润深度(P=0.009)、淋巴结转移(P=0.001)、Ddukes分期(P=0.002)均呈负相关.MUC5AC阳性表达率分别为30%、46.7%(P=0.296);在大肠腺癌中MUC5AC的阳性表达与分化程度(P=0.005)正相关,与浸润深度呈负相关(P=0.039).MUC2与MUC5AC无相关性.结论大肠腺癌组织MUC2的下调表达可能参与了大肠腺癌的发生,对临床上判断预后具有较大的意义.

Expression of MUC2 and MUCSAC Colorectal adenocarcinoma and Their Clinical Significance

Objective To investigate the relation between the expression of MUC2 and MUCSAC in colorectal adenocarcinoma and its clinical pathological parameters. Methods The expression of MUC2, MUC5AC were detected in 20 colorectal adenomas and 60 colorectal adenocarcinomas by immunohistochemical method. Remllts In 20 colorectal adenoma and 60 colorectal adenocarcinomas the positive expression rates of MUC2 were 100% and 58.3%（P=0.000） respectively. MUC2 expression in colorectal adenocarcinoma was positive correlated to the survival period（P=0.008）, negative correlated to the depth of invasion（P=0.009）, lymph node metastasis（P=0.001）, Dukes staging（P=0.002）. The expression rates of MUC5AC were 30% and 46.7%（P=0.296） respectively, MUC5AC expression in colorectal adenocarcinoma was positive correlated to differentiation（P=0.005）, negative correlated to the depth of invasion（P=0.039）. MUC2 and MUC5AC no correlation. Conclusions The down-regulation of MUC2 expression may be involved in carcinogenesis. And it is very important to predict the prognosis in colorectal adenocarcinomas.