育龄人群孕前强化麻疹疫苗对阻断“双相移位”的应用价值

目的探讨育龄人群强化麻疹疫苗（MV）注射前后麻疹免疫水平,进一步分析育龄男女麻疹免疫水平对消除麻疹的影响,为最终实现消除麻疹目标提供科学依据。方法选择本院22-35岁育龄医护人员60名,观察MV注射前及注射后26个月的麻疹免疫水平的差异,并采用酶联免疫吸附试验（ELISA）,对其MV免疫前后的血清分别检测IgM和IgG抗体。结果育龄男女接种MV前后χ2检验结果：在1 200水平上,χ2=7.32,P〈0.05;在1 800水平,χ2=10.25,P〈0.05;注射前后麻疹免疫水平有统计学差异。结论育龄男女或夫妻双方孕前及时、安全接种MV,既可提高育龄人群麻疹抗体水平,同时也可提高出生8月龄婴儿麻疹疫苗初免之前胎传麻疹抗体水平,从而有效降低25岁以上人群及8月龄内婴儿麻疹发病,达到＂一代免疫,两代受益＂的效果,对阻断＂双相移位＂具有重要意义。

The Application Value of Strengthening Measles Vaccine to Block Biphase Displacement for People of Childbearing Age before Pregnancy

Objectives Explore the measles immunity levels before and after strengthening measles vaccine（MV） injection for childbearing age population,and further analyze the impact of the childbearing aged women and men＇s measles immunization level on measles elimination to provide a scientific basis for the ultimate realization of the measles elimination goal.Methods Select 60 child-bearing aged hospital medical staff ranged from 22 to 35-year-old and observe the differences in measles immunization levels before and after 26 months of MV injection,also adopt enzyme-linked immune sorbent assay test（ELISA） to detect the IgM and IgG antibodies of serum before and after its MV immunity.Results The χ2 test result before and after the women and men of reproductive age were inoculated： in 1 200 level,χ2=7.32,P0.05,in 1 800 level,χ2=10.25,P0.05;there exists statistical differences in measles immunization levels before and after the injection.Conclusion Women and men of reproductive age or couples inoculate MV timely and safely before pregnancy can not only improve the level of measles antibody of childbearing aged people but also can improve the 8-month-old infants＇ measles antibody level of fetal transmission of measles before measles vaccine,which is able to effectively reduce the incidence of measles among people over 25 years old and below 8-month-old infant,so that the effect of ‘one generation immune while two generations benefit＇ can be achieved.It is significant for blocking biphase displacement.