他汀类药物治疗慢性心力衰竭的疗效及预后影响研究

目的:评价他汀类药物对慢性心力衰竭(CHF)患者疗效和预后的影响。方法:自2010年1月起共入选了我院、卢湾区中心医院及闵行区中心医院确诊的240例纽约心功能分级Ⅱ~Ⅳ级慢性收缩性心力衰竭患者左心室射血分数(LVEF)≤45%],按照患者是否用他汀类药物治疗分为治疗组和对照组,每组各120例,比较2组患者治疗前后血脂、血清氨基末端脑钠肽前体(NT-proBNP)、炎症因子高敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)的变化,以及心脏超声监测心腔大小及LVEF变化。观察2组患者的生存率及终点事件发生率。结果:与对照组相比,治疗组血脂水平及血清NT-proBNP、hs-CRP、TNF-α水平降低(P

The therapeutic and prognostic effect of statins on chronic heart failure

Objective To evaluate the therapeutic and prognostic effect of statins in patients with chronic heart failure （CHF）. Methods A total of 240 heart failure patients with New York Heart Association （NYHA） Class Ⅱ-Ⅳleft ventrieular ejection fraction （LVEF ≤45%）] from our hospital, Lu Wan District Central Hospital and Min Hang District Central Hospital were enrolled in this study. Patients were assigned into two group with 120 patients each according to whether statins was taken or not. The changes of cholesterol level, serum N-terminal probrain natriuretie peptide （NT- proBNP）, high sensitive C reactive protein （hs-CRP）, tumor necrosis factor-alpha （TNF-α）, and the differences of LVEF and eardiae ehamber size by eehoeardiography monitoring before and after treatment were eompared between the two groups. Furthermore, the survival rate and endpoint event rate were eompared. Results As eompared with non-statins group, serum NT-proBNP, hs-CRP and TNF-α were decreased signifieantly in statins group, while LVEF was increased （41.5% vs 42.8%, P=0.034） and cardiac chamber size was reduced. Survival rate increased （92.5% vs 80.8%, P=0.013） and end point event rate decreased in statins group （38.3% vs 57.5%, P=0.006）. Conclusions CHF patients treated with statins had a lower serum cholesterol, NT-proBNP, hs-CRP and TNF-α level and reduced eardiae chamber size, but higher LVEF and survival rate and fewer endpoint events, suggesting that statins eould improve the prognosis of CHF.