绝经后妇女雌激素受体基因多态性与骨密度的相关性

目的:探讨雌激素受体(ER)基因XbaⅠ及PvuⅡ多态性与广州地区部分汉族绝经后妇女骨密度相互关系。方法:随机筛选年龄42～75岁广州汉族妇女157例,采用双能X线吸收法测其全身、腰椎2～4、股骨颈、Ward'三角和大转子区等部位的骨密度值,并采用聚合酶链反应限制性片段长度多态性方法检测其外周血白细胞基因组ER基因型。结果:157例受试对象中,ER基因XbaⅠ及PvuⅡ基因型分布均符合Hardy-Weinberg定律。携带XXPp基因型的个体在多个部位拥有较高的骨密度值,差异有统计学意义。结论:ER基因XbaⅠ及PvuⅡ多态性与广州汉族绝经后妇女的骨密度有一定的相关性,XXPp是一种对骨量有益的基因型。

Effect of estrogen receptor genotypes on bone mineral density in postmenopausal women

Objective To study the relationship between the polymorphism of XbaⅠand PvuⅡgenotypes in estrogen receptor(ER)in postmenopausal women and their bone mineral density(BMD).Methods 157 aged 42～75 women from Chinese Han ethnic group in the Guangzhou area were recruited to the study.For each study subject,BMD of total skeleton,lumbar vertebrae(L2～4),and femur(greater trochanter,the neck,and the Ward's triangle)were measured by dual-energy X-ray absorptiometry(DEXA).The genotypes of estrogen receptor gene were de...