妊娠妇女性激素、骨密度、骨代谢生化指标的变化及相关性研究

目的：探讨妊振妇女骨密度和骨代谢的变化及其与性激素的关系。方法：随机选取63例健康脑力劳动孕妇和21例健康脑力劳动妇女分别测定骨密度，血清Ca、P、ALP、BGP和E2、P、FSH、LH、PRL以及尿HP/Cr、Ca/Cr比值。结果：孕期骨密度虽有下降但无显变化（P＞0.05)，ALP和BGP在晚孕期有显变化（P＜0.05)且此变化与E2成正相关（r=0.61、0.36)。结论：妊娠期骨密度虽无明显变化，但晚孕期骨转换率明显增加且与E2呈正相关。提示可通过测定E2了解孕期骨代谢情况，并及时予以补钙等措施可能有益。

Changes in bone mineraldensity and biochemical markers of bon e metabolism in normal pregnancy

Objective To explore the changes in bone mineral density (BMD)and biochemical markers of bone metabolism in normal pregnancy.Methods BMD and serum concentrations of calcium(Ca),phosphorus(P),alkaline phosphatase(ALP),osteocalcin(BGP),E 2,P,FSH,LH,and PRL were measured in 63 normal mental working pregnant women and 21 normal fertile mental working women.Fasting urinary hydroxyproline/creatinine ratio(HP/Cr)and calcium/creatinine ratio(Ca/Cr)were also measured.Results No significant difference in BMD was found during pregnancy( P >0.05).Serum concentrations of ALP and BGP rose rapidly in the third trimester,which was significantly different from the other groups( P <0.05) and was significantly positively related to E 2. Conclusion Pregnancy has no significant effect on BMD.Changes in serum and urine markers of bone formation and resorption suggest that bone turnover may be significantly increased in the third trimester.There is a significantly positive correlation between bone turnover rate and E 2.;