Platelet MAO and measures of attention and impulsivity in boys with attention deficit disorder and hyperactivity |
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| Authors: | W O Shekim D B Bylund J Alexson R D Glaser S B Jones K Hodges S Perdue |
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| Institution: | 1. Walid O. Shekim, M.D., Joyce Alexson, Ph.D., and Sondra Perdue, D.P.H., are from the Neuropsychiatric Institute, University of California, Los Angeles, USA;2. David B. Bylund, Ph.D., Associate Professor, Department of Pharmacology, University of Missouri-Columbia, USA;3. Kay Hodges, Ph.D., is Associate Professor and Director of Child Outpatient Clinic, Department of Psychiatry, USA;4. Robert D. Glaser, M.Sc., is Research Assistant, Mid-Missouri Mental Health Center and the Department of Psychiatry, University of Missouri-Columbia, USA;5. Susan B. Jones, M.Sc., is Senior Research Specialist, Department of Pharmacology, University of Missiouri-Columbia, USA;1. University of Texas, Permian Basin, 4901 East University, Odessa, TX 79762, USA;2. University of Münich and CESifo, Shackstrasse 4, 80539 Münich, Germany;2. Department of Paediatrics, Division of Paediatric Cardiology, Western University, London, Canada;3. Children’s Health Research Institute, London, Canada;4. Paediatric Cardiopulmonary Research Laboratory, London Health Sciences Centre, London, Canada;5. Department of Paediatric Cardiology and Intensive Care Medicine, University of Goettingen, Goettingen, Germany |
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| Abstract: | Platelet monoamine oxidase (MAO) activity was studied in 22 boys diagnosed as having attention deficit disorder with hyperactivity and 12 healthy control boys admitted to a clinical research center and placed on a diet low in monoamines. The hyperactive boys had lower platelet MAO activity than controls, and MAO activity was related to performance on the Matching Familiar Figures Test (MFF) and the Continuous Performance Test (CPT), which yield scores sensitive to impulsivity and inattention. Furthermore, it was negatively related, in hyperactive boys only, to two tests of reading and spelling achievement. Administration of d-amphetamine and placebo in a double-blind crossover design did not significantly raise MAO levels above baseline and was minimally related to improved performance on the MFF and CPT. |
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