| 糖酵解抑制剂抗癫痫机制的新研究进展 |
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| 引用本文： | 阳衡,伍炯星,郭韧,彭毓棻,郑文,刘鼎,宋治.糖酵解抑制剂抗癫痫机制的新研究进展[J].中国新药与临床杂志,2012(7):381-385. |
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| 作者姓名： | 阳衡 伍炯星 郭韧 彭毓棻 郑文 刘鼎 宋治 |
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| 作者单位： | 中南大学湘雅三医院神经内科 |
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| 基金项目： | 国家自然科学基金资助项目(30971534);中南大学湘雅三医院“125人才工程”建设项目;中南大学湘雅三医院重点学科建设项目 |
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| 摘 要： | 神经细胞兴奋性的代谢调节作为控制癫痫发作的一个重要因素已经逐步被认识到。糖酵解抑制剂生酮饮食、2-脱氧葡萄糖、1,6-二磷酸果糖通过降低神经细胞的兴奋性从而发挥抗癫痫作用,其疗效在临床上已经明确,但是其具体抗癫痫机制尚不完全清楚。本文对其抗癫痫机制的新研究进展进行综述。
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| 关 键 词： | 癫痫 糖酵解 糖酵解抑制剂 抗惊厥药 |
Progress on antiepileptic mechanism of glycolysis inhibitor |
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| YANG Heng,WU Jiong-xing,GUO Ren,PENG Yu-feng,ZHENG Wen,LIU Ding,SONG Zhi.Progress on antiepileptic mechanism of glycolysis inhibitor[J].Chinese Journal of New Drugs and Clinical Remedies,2012(7):381-385. |
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| Authors: | YANG Heng WU Jiong-xing GUO Ren PENG Yu-feng ZHENG Wen LIU Ding SONG Zhi |
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| Institution: | (Department of Neurology,the Third Xiangya Hospital,Central South University,Changsha HU-NAN 410013, China) |
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| Abstract: | Metabolic regulation of neuronal excitability was increasingly recognized as an important factor in seizure control.Reducing the excitability of nerve cells is the way which ketogenic.diet,2-deoxy-D-glucose and fructose-1,6-bisphosphate provides the antiepileptic effects.Although the specific antiepileptic mechanism is not fully understood,good clinical effects of glycolysis inhibitor were obtained.In this article,the progress on the antiepileptic mechanism of glycolysis inhibitor was reviewed. |
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| Keywords: | epilepsy glycolysis glycolysis inhibitor anticonvulsants |
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