| 预混门冬胰岛素强化治疗对2型糖尿病患者血浆中成纤维细胞生长因子-21水平的影响 |
| |
| 引用本文： | 曾俊,李伶,杨刚毅,李钶,李生兵,陈文雯. 预混门冬胰岛素强化治疗对2型糖尿病患者血浆中成纤维细胞生长因子-21水平的影响[J]. 华西医学, 2011, 0(6): 807-810 |
| |
| 作者姓名： | 曾俊 李伶 杨刚毅 李钶 李生兵 陈文雯 |
| |
| 作者单位： | 重庆医科大学附属第二医院内分泌科;成都医学院临床技能中心;重庆医科大学检验系临床生化教研室和教育部实验诊断重点实验室 |
| |
| 基金项目： | 国家自然科学基金资助项目(30771037,30871199,30971388)~~ |
| |
| 摘 要： | 目的 探讨预混门冬胰岛素对2型糖尿病(type 2 diabetes mellitus,T2DM)患者血浆成纤维细胞生长因子-21(fibroblast growth factor-21,FGF-21)水平的影响.方法 2008年2-12月采用酶联免疫吸附试验测定44例正常人及37例采用预混门冬胰岛素治疗前后的T2DM...
|
| 关 键 词： | 成纤维细胞生长因子-21 2型糖尿病 人胰岛素类似物 |
Effects of Aspart Insulin Thrice Daily Treatment on Plasma Fibroblast Growth Factor-21 Level in Patients with Type 2 Diabetes Mellitus |
| |
| ZENG Jun,LI Ling,YANG Gang-Yi,LI Ke,LI Sheng-bing,CHEN Wen-wen. Effects of Aspart Insulin Thrice Daily Treatment on Plasma Fibroblast Growth Factor-21 Level in Patients with Type 2 Diabetes Mellitus[J]. West China Medical Journal, 2011, 0(6): 807-810 |
| |
| Authors: | ZENG Jun LI Ling YANG Gang-Yi LI Ke LI Sheng-bing CHEN Wen-wen |
| |
| Affiliation: | 1.1.Department of Endocrinology,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,P.R.China;2.Clnical Skill Center,Chengdu Medical College,Chengdu,Sichuan 610083,P.R.China;3.Clinical Biochemistry Branch of the Department of Laboratory Medicine,and Key Laboratory of Experimental Diagnosis of the Ministry of Education,Chongqing Medical University,Chongqing 400010,P.R.China |
| |
| Abstract: | Objective To investigate the effects of treatment with aspart insulin on plasma fibroblast growth factor-21（FGF-21） levels in patients with type 2 diabetes mellitus（T2DM）.Methods From February to December 2008,plasma FGF-21 levels were measured by enzyme-linked immunosorbent assay in 37 patients with T2DM treated with aspart insulin and 44 normal controls.The relationship between plasma FGF-21 levels and body mass index（BMI）,percentage of body fat（FAT%）,waist-hip ratio（WHR）,blood lipid,blood glucose,hemoglobin A1c（HbA1c）,and free fatty acid（FFA） was analyzed.Results Before treatment,plasma FGF-21 level was significantly higher in T2DM patients [（1.79±0.04） μg/L] than that in the normal controls [（1.35±0.21） μg/L]（P0.01）.After 16 weeks of treatment with premixed human insulin analogues（BIAsp 50 and BIAsp 30）,FFA,HbA1c,fasting plasma glucose and 2-hour postprandial blood glucose decreased significantly（P0.01）,and fasting plasma FGF-21 level decreased to（1.33±0.39） μg/L which was significantly different from that before treatment（P0.01）.Correlation analysis showed that plasma FGF-21 level was positively correlated with BMI（r=0.53,P0.01）,which was an independent factor in influencing the FGF-21 level in the patients.Conclusion Aspart insulin treatment can remarkably improve glucose metabolism and significantly decrease the fasting plasma FGF-21 level. |
| |
| Keywords: | Type 2 diabetes mellitus Fibroblast growth factor-21 Human insulin analogues |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
