基因重组人生长激素和雌/孕激素治疗Turner综合征患儿疗效观察

目的 探讨基因重组人生长激素(recombinant human growth hormone,rhGH)及雌/孕激素(estrogen/progestogem,E/P)治疗对Turner综合征(Turner syndrome,TS)患儿身高及性征发育的影响.方法 2005年1月-2009年6月四川大学华西第二医院门诊...

Effects of Recombinant Human Growth Hormone and Sex Hormone on Children with Turner Syndrome

Objective To explore the therapeutic effects of recombinant human growth hormone（rhGH） and sex hormone on the stature and sex feature of children with Turner syndrome（TS）.Methods A total of 22 children with TS were selected in the outpatients department of West China Second Hospital between January 2005 and June 2009.Twelve children with TS the average age of（13.58±2.23） years] received rhGH 0.15 U/（kg·d）] every night before sleep for 4-24 months.Sixteen children with TS（age≥14 years old,bone age≥11 years old） underwent estrogen and progestogen（E/P） treatment for 3-30 months.Results The height and height standard deviation score increased significantly in children with rhGH therapy（P0.01）.The height velocity was（9.33±2.39）cm/year after the treatment.The treatment of estrogen and progestogen could promote the development of breast and establish menstrual cycle in children with TS.Conclusion rhGH and E/P can play a significant role in treatment of TS in children.