类风湿关节炎患者发生动脉硬化的影响因素分析

目的 采用高分辨率超声测定类风湿关节炎(rheumatoid arthritis,RA)患者颈动脉内中膜厚度和是否有斑块以及是否存在动脉硬化.方法 分析2009年4月-2010年9月间150例RA患者的一般情况、发病情况、疾病活动性评分(DAS28评分),及实验室指标如:血沉(ESR)、C反应蛋白(CRP)、抗环瓜氨酸...

Incidence Rate of Arteriosclerosis in Patients with Rheumatoid Arthritis

Objective To detect the carotid artery intima-media thickness and the existence of carotid plague and arteriosclerosis by high-resolution ultrasonography in patients with rheumatoid arthritis（RA）.Methods A total of 150 RA patients treated in our hospital between April 2009 and September 2010 were included in this study.Their general condition,onset of the disease and disease activity score（DAS28 scoring） were analyzed.Laboratory indexes like erythrocyte sedimentation rate（ESR）,C reactive protein（CRP）,Anti-cyclic citrullinated peptide（ACCP） antibody,rheumatoid factor（RF）,total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,apolipoprotein A1（apo A1）,apolipoprotein B（apo B）,lipoprotein（a）（Lp（a））,and uric acid（UA） were measured.Carotid color ultrasonography was used to detect the carotid intima-media thickness and the existence of carotid plague in 150 patients with RA and 120 patients in the control group.Results Twenty out of the 150 RA patients and three out of the 120 controls manifested arteriosclerosis.Single factor analysis showed a correlation between arteriosclerosis in RA patients and course of disease,DAS28 scoring,Apo A,Apo B,HDL-C,and UA,and no correlation between arteriosclerosis and age,gender,ESR,CRP,RF,and ACCP.Multivariate regression analysis showed that the course of disease,UA and HDL-C are independent risk factors for arteriosclerosis in RA patients.Conclusion Analysis of the carotid intima-media has a certain clinical value in predicting arteriosclerosis in RA patients.