不同糖耐量水平人群血浆胰高血糖素样肽-1和葡萄糖依赖的促胰岛素样多肽水平比较

目的 了解不同糖代谢状态的人群空腹及口服葡萄糖耐量实验(oral glucose tolerance test,OGTT)餐后胰高血糖素样态-1(GLP-1)和葡萄糖依赖的促胰岛素多态(GIP)水平.方法 将受试者根据OGTT结果分为3组:正常糖耐量组(NGT,n=61例),糖耐量受损组(IGT,n=53)和2型糖尿病...

A Study on the Levels of Glucagon-like Peptide-1 and Glucose-dependent Insulinotropic Polypeptide in People with Different Glucose Tolerance Degrees

Objective To investigate the fasting,and after oral glucose tolerance test（OGTT）,the postprandial levels of glucagon-like peptide-1（GLP-1） and glucose-dependent insulinotropic polypeptide（GIP） in Chinese people with different degrees of glucose tolerance.Methods Based on the results of OGTT,180 subjects were divided into three groups：normal glucose tolerance group（NGT group,n=61）,impaired glucose tolerance group（IGT group,n=53） and type-2 diabetes mellitus group（T2DM group,n=66）.Fasting venous blood and the venous blood 2 hours after OGTT was sampled to detect GLP-1 and GIP levels.Results The fasting GLP-1 level in the T2DM group was significantly lower than that in the NGT and IGT groups（P0.05）.There was no significant difference in fasting GLP-1 level between NGT and IGT groups（P0.05）.There was no significant difference in GLP-1 level 2 hours after OGTT among all the three groups（P0.05）.GIP level gradually increased in the order of NGT,IGT and T2DM both before and after glucose load,and it was positively correlated with glucose levels just after OGTT and 2 hours after OGTT（r=0.384,0.426;P0.05）.Conclusion Different GLP-1 and GIP levels may be one of the reasons for different insulin secretion ability between IGT and T2DM.