| 老年大鼠急性心肌梗死模型的制作 |
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| 引用本文： | 梁艳虹,缪国斌,张健.老年大鼠急性心肌梗死模型的制作[J].华西医学,2011(7):1025-1027. |
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| 作者姓名： | 梁艳虹 缪国斌 张健 |
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| 作者单位： | 首都医科大学附属北京朝阳医院综合科;首都医科大学附属北京友谊医院综合科 |
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| 摘 要： | 目的 用老年大鼠建立一种与人类发病年龄相符的稳定可重复的急性心肌梗死动物模型.方法 Wistar大鼠经戊巴比妥钠麻醉后,气管切开插管,连通呼吸机,开胸后结扎左冠状动脉前降支.分不同时间点测血流动力学后取出心脏行病理组织学观察.结果 成功建立老年大鼠心肌梗死模型并进行病理组织学验证.结论 建立老年大鼠心梗模型是可靠的,有...
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| 关 键 词： | 老年大鼠 急性心肌梗死 血流动力学 动物模型 |
Study on the Development of Acute Myocardial Infarction Model in Old Rats |
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| LIANG Yan-hong,MIAO Guo-bin,ZHANG Jian.Study on the Development of Acute Myocardial Infarction Model in Old Rats[J].West China Medical Journal,2011(7):1025-1027. |
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| Authors: | LIANG Yan-hong MIAO Guo-bin ZHANG Jian |
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| Institution: | 1.General Department,Beijing Chaoyang Hospital,Capital University of Medical Sciences,Beijing 100020;2.Beijing Youyi Hospital,Capital University of Medical Sciences,Beijing 100050;P.R.China |
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| Abstract: | Objective To develop a steady and repeatable acute myocardial infarction model in old rats in accordance to human age.Methods Wistar rats were anaesthetized with sodium phenobarbital.After tracheotomy intubation,respiration machine was linked.Left anterior thoracotomy was performed to ligate the left anterior descending coronary artery.After hemodynamic parameters were obtained at various time points,hearts of the rats were taken for pathologic and histological examinations.Results The model of acute myocardial infarction in old rats was established successfully and proved by pathologic and histological staining.Conclusion It is reliable to establish the myocardial infarction model in old rats,which is helpful in guiding clinical practices. |
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| Keywords: | Old rats Acute myocardial infarction Hemodynamic parameters Animal model |
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