乳腺浸润性导管癌组织中表皮钙黏蛋白的表达及其意义

目的 探讨乳腺浸润性导管癌中表皮钙黏蛋白(E-cadherin,E-cad)的表达及其意义.方法 选取2005年1月-2009年12月的组织病理切块,用免疫组织化学EnVision二步法检测63例乳腺浸润性导管癌(invasiveductal carcinoma,IDC)组织中E-cad的表达情况,设为IDC组;另检测...

Expression of E-cadherin in Invasive Ductal Carcinoma of the Breast and Its Significance

Objective To explore the expression of the protein E-cadherin（E-cad） in invasive ductal carcinoma（IDC） of the breast and its significance.Methods We chose 63 cases of pathological wax with IDC between 2005 and 2009,and immunohistochemical EnVision method was used to detect the expression of E-cad protein in these cases which were designated to be the IDC group.At the same time,the E-cad expression in 15 cases of breast adenoma and another 15 cases of breast lobular hyperplasia were also detected,and these cases were designed to the the control group.The expression of E-cad in these two groups were compared.Results The positive rates of E-cad protein expression in the IDC group and the control group were respectively 58.7% and 80.0% with a significant difference between the two groups（P0.05）.In the IDC group,the positive rates of E-cad protein expression in patients aged38 and ≥38 years old were respectively 54.2% and 61.5% without a significant difference（P0.05）.The positive rates of E-cad protein expression for tumors with a diameter 3 cm and ≥3 cm were respectively 54.8% and 66.7% without a significant difference（P0.05）.The positive rates of E-cad protein expression for class Ⅰ＋Ⅱ tumors and class Ⅲ tumors were respectively 76.3% and 32.0% with a significant difference（P0.05）.The positive rates of E-cad protein expression for patients without and with axillary lymph node metastasis were respectively 78.3% and 47.5% with a significant difference（P0.05）.Conclusions The expression of E-cad is correlated with histological classification and lymph node metastasis and was not related to tumor size and age of the patients.The expression of E-cad is higher in IDC patients without lymph node metastasis than that in IDC patients with lymph node metastasis,which indicates that E-cad is an important index for lymph node metastasis of IDC.