Synthesis and Antimicrobial Activity of 5-(R1-benzyl)-2-(R2-benzylidenehydrazono)-3-(2-furylmethyl)Thiazolidin-4-ones

3-Aryl-2-bromopropanoic acid esters react with furfurylthiosemicarbazones of benzaldehyde and 4-chlorobenzaldehyde to form 5-(R¹-benzyl)-2-(4-R-benzylidenehydrazono)-3-furfuryl-4-thiazolidinones (R = H, 4-Cl; R¹ = 4-Me, 4-F, 4-Cl). The antimicrobial activity of the synthesized compounds was studied, and it was established that only the compounds with R¹ = Me are active. The replacement of methyl group by halogen results in the loss of antimicrobial activity. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 5, pp. 20 – 22, May, 2005.