云南省腾冲市住院病人溶组织内阿米巴感染情况及影响因素分析

目的　了解云南省腾冲市住院病人溶组织内阿米巴感染情况及其影响因素。方法　2016?07?01–2017?03?31，采用横断面调查方法对云南省腾冲市人民医院住院病例进行问卷调查。无菌采集其粪便样本，通过巢氏PCR检测溶组织内阿米巴感染情况。采用[χ2]检验和多因素logistic回归模型分析溶组织内阿米巴感染的影响因素。结果　共调查507名住院患者，其中10名患者感染溶组织内阿米巴，感染率为1.97%（95% CI：1.07%～3.59%）。溶组织内阿米巴感染者和非感染者身高（Z = -0.40，P = 0.69）、体重（Z = -0.34，P = 0.73）、体重指数（Z = -0.40，P = 0.69）和年龄（Z = -1.48，P = 0.14）差异无统计学意义。慢性腹泻（OR = 21.43，95% CI：5.04～91.23）和日常饮用水（OR = 11.28，95% CI：2.79～45.56）是人感染溶组织内阿米巴的影响因素。溶组织内阿米巴感染和腹胀（OR = 0.70，95% CI：0.09～5.56）、食欲不振（OR =0.50，95% CI：0.06～4.02）、皮肤瘙痒（OR = 0.79，95% CI：0.10～6.38）、肛周瘙痒（OR = 1.74，95% CI：0.21～14.07）及便秘（OR = 0.91，95% CI：0.13～7.33）无统计学关联。结论　云南省腾冲市住院病人溶组织内阿米巴感染率较高，慢性腹泻和饮用未煮沸的水与溶组织内阿米巴感染呈高度相关。

Prevalence of Entamoeba histolytica infection and its risk factors in Tengchong City,Yunnan Provine: a hospital-based study

Objective　To understand the infection status and risk factors of Entamoeba histolytica in inpatients in Tengchong City, Yunnan Province. Methods　A cross?sectional study was conducted in the inpatients in Tengchong People’s Hospital, Yunnan Province. After obtaining the informed consent from the subjects, the stool samples were collected from 2016?07?01 to 2017?03?31, and nested polymerase chain reaction (PCR) was used to detect E. histolytica in the stool samples. Meanwhile, a structured questionnaire was used to record the demographic information and clinical symptoms for the patients. Results　Totally 507 cases were recruited, and the detection rate of E. histolytica was 1.97% (10/507, 95% CI: 1.07%-3.59%) in all subjects. There were no significant differences between the inpatients with and without E. histolytica infection in the height (Z = -0.40, P = 0.69), weight (Z = -0.34, P = 0.73), body mass index (Z = -0.40, P = 0.69) and age (Z = -1.48, P = 0.14). Chronic diarrhea (OR = 21.43, 95% CI: 5.04-91.23) and daily drinking water (OR = 11.28, 95% CI: 2.79-45.56) were relevant to E. histolytica infection. No significant association was observed between E. histolytica infection and the clinical symptoms, such as abdominal distension (OR = 0.70, 95% CI: 0.09-5.56), inappetence (OR = 0.50, 95% CI: 0.06-4.02), itchy skin (OR = 0.79, 95% CI: 0.10-6.38), perianal pruritus (OR = 1.74, 95% CI: 0.21-14.07), and constipation (OR = 0.91, 95% CI: 0.13-7.33). Conclusion　E. histolytica infection is high in inpatients in Tengchong City, Yunnan Province, and chronic diarrhea and drinking unboiled water were highly correlated with E. histolytica infection.