| 急性心肌梗死患者血浆中MEG3和UCA1的表达水平及临床意义 |
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| 引用本文： | 刘崇韬,翁志远,郑志虹. 急性心肌梗死患者血浆中MEG3和UCA1的表达水平及临床意义[J]. 心血管康复医学杂志, 2019, 0(3): 285-289 |
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| 作者姓名： | 刘崇韬 翁志远 郑志虹 |
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| 作者单位： | 佳木斯市中心医院心内一科 |
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| 摘 要： | 目的:探讨急性心肌梗死(AMI)患者血浆中人类母系表达基因3(MEG3)和尿路上皮癌抗原1(UCA1)表达水平及其临床意义。方法:选择我院收治的90例AMI患者为AMI组,同时期50例在我院体检健康者为健康对照组,观察并比较健康对照组及AMI组发病后不同时间点(1h、3h、6h、12h)血浆MEG3、UCA1表达及血清肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白I(cTnI)水平变化,采用Spearman相关分析其相关性。结果:与健康对照组比较,AMI患者发病1h后血浆MEG3[(0.002±0.001)比0.017±0.003)]表达显著升高,UCA1[(0.027±0.005)比(0.017±0.002)]表达显著降低(P均=0.001);3h后AMI患者血清CK-MB[(20.01±3.05)IU/L比(32.10±4.40)IU/L]、cTnI[(1.01±0.87)ng/L比(2.10±0.91)ng/L]水平均显著升高(P均=0.001)。Spearman相关分析显示:AMI患者血浆MEG3表达与血清CK-MB、cTnI水平呈显著正相关(r=0.351、0.368,P均<0.05);而血浆UCA1表达与血清CK-MB、cTnI水平呈显著负相关(r=-0.416、-0.425,P均<0.01)。结论:急性心肌梗死发作早期患者血浆中人类母系表达基因-3显著升高,尿路上皮癌抗原1显著降低,两者与CK-MB、cTnI水平有显著相关性,可作为急性心梗早期确诊的新型标志物。
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| 关 键 词： | 心肌梗死 RNA 诊断 |
Plasma expression levels of MEG3 and UCA1 in patients with acute myocardial infarction and their clinical significance |
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| LIU Chong-tao,WENG Zhi-yuan,ZHENG Zhi-hong. Plasma expression levels of MEG3 and UCA1 in patients with acute myocardial infarction and their clinical significance[J]. Chinese Journal of Cardiovascular Rehabilitation Medicine, 2019, 0(3): 285-289 |
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| Authors: | LIU Chong-tao WENG Zhi-yuan ZHENG Zhi-hong |
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| Affiliation: | (First Department of Cardiology, Central Hospital of Jiamusi City, Jiamusi, Heilongjiang, 154002, China) |
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| Abstract: | LIU Chong-tao;WENG Zhi-yuan;ZHENG Zhi-hong(First Department of Cardiology, Central Hospital of Jiamusi City, Jiamusi, Heilongjiang, 154002, China) |
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| Keywords: | Myocardial infarction RNA Diagnosis |
| 本文献已被 CNKI 维普 等数据库收录！ |
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