氯吡格雷、阿司匹林联合丁苯酞对进展性脑梗死患者神经功能及生活质量的影响

目的探讨氯吡格雷、阿司匹林联合丁苯酞对进展性脑梗死患者神经功能及生活质量的影响。方法本研究选取2016年1月-2018年12月在河南省某医院就诊的196例进展性脑梗死患者作为研究对象,采用随机数字表法将患者分为对照组与研究组,每组98例。对照组患者采用氯吡格雷+阿司匹林进行治疗;研究组患者在对照组患者治疗基础上加用丁苯酞进行治疗。治疗2周时,比较2组患者的治疗效果;比较2组患者治疗前及治疗1周、2周时美国国立卫生院卒中量表(NIHSS)评分;比较2组患者治疗2周时不良反应发生情况;比较2组患者治疗前及随访6个月时Barthel指数评定量表(BI)及世界卫生组织生活质量评定量表(WHOQOL-100)评分。结果研究组患者治疗总有效率为94.90%,高于对照组的80.61%,差异有统计学意义(P<0.05)。治疗1周、2周时,研究组患者NIHSS评分分别为(10.48±1.91)分及(4.85±0.98)分,低于对照组的(13.64±2.78)分及(6.97±1.47)分,差异均有统计学意义(P<0.05)。研究组、对照组患者不良反应总发生率分别为7.14%及5.10%,差异无统计学意义(P>0.05)。随访6个月时,研究组患者BI及WHOQOL-100评分分别为(89.28±6.31)分及(88.26±7.84)分,均高于对照组的(74.29±5.18)分及(75.35±5.07)分,差异均有统计学意义(P<0.05)。结论采取丁苯酞+氯吡格雷+阿司匹林治疗进展性脑梗死的临床效果确切,其可改善患者神经功能,提高患者日常生活能力及生活质量,安全有效,值得临床推广应用。

Effect of clopidogrel,aspirin combined with sodium butyphthalide on neurological function and quality of life in patients with progressive cerebral infarction

Objective To investigate the effect of clopidogrel and aspirin combined with sodium butyphthalide injection on neurological function and quality of life in patients with progressive cerebral infarction.Methods From January 2016 to December 2018,196 patients with progressive cerebral infarction in a hospital in Henan province were selected as the study subjects.Patients in the control group were treated with clopidogrel,aspirin,and patients in the study group were treated with sodium butyphthalide on the basis of treatment in the control group.At 2 weeks of treatment,the therapeutic effect of 2 groups of patients was compared The US National Hospital Stroke Scale(NIHSS)scores were compared between 2 groups of patients before treatment and at 1 and 2 weeks of treatment.The adverse reaction rates were compared between 2 groups of patients at 2 weeks of treatment.Results The total effective rate of treatment in the study group was 94.90%,which was higher than 80.61%in the control group,and the difference was statistically significant(P<0.05).The NIHSS scores in the study group were(10.48±1.91)and(4.85±0.98),lower than the control group(13.64±2.78)and(6.97±1.47),the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group and the control group was 7.14%and 5.10%,respectively,and the difference was not statistically significant(P>0.05).The scores of BI and WHOQOL-100 in the study group were(89.28±6.31)and(88.26±7.84),respectively,higher than those in the control group(74.29±5.18)and(75.35±5.07),the difference was statistically significant(P<0.05).Conclusion Clopidogrel,sodium butyphthalide and aspirin,is effective in the treatment of progressive cerebral infarction.It can improve the nerve function,the daily life ability and quality of life of the patients.