| 基因治疗新策略——酶性DNA的设计和应用 |
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| 引用本文： | 于乐成,顾长海,王升启,毛青.基因治疗新策略——酶性DNA的设计和应用[J].中国药物化学杂志,2002,12(4):236-242. |
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| 作者姓名： | 于乐成 顾长海 王升启 毛青 |
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| 作者单位： | 1. 第三军医大学西南医院全军感染病研究所,重庆,400038
2. 军事医学科学院放射医学研究所,北京,100850 |
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| 摘 要： | 本文综述了能够剪切RNA分子的酶性DNA的种类、结构、作用机制、动力学特征及其在用作新型基因治疗药物方面的优势、设计要点、应用现状与前景等最新研究进展。
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| 关 键 词： | 基因治疗 酶性DNA 设计 应用 脱氧核酶 药物设计 |
| 文章编号： | 1005-0108(2002)04-0236-07 |
New strategy in the gene therapy:design and application of catalytic DNA |
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| YU Yue cheng ,GU Chang hai ,WANG Sheng qi ,MAO Qing.New strategy in the gene therapy:design and application of catalytic DNA[J].Chinese Journal of Medicinal Chemistry,2002,12(4):236-242. |
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| Authors: | YU Yue cheng GU Chang hai WANG Sheng qi MAO Qing |
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| Institution: | YU Yue cheng 1,GU Chang hai 1,WANG Sheng qi 2,MAO Qing 1 |
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| Abstract: | Catalytic DNAs,also named deoxyribozymes,DNAzymes or DNA enzymes,were synthetic oligodeoxynuckeotides able to specifically bind and cleave different target RNAs.10 23,8 17 and HD2 deoxyribozymes were the main catalytic DNAs that have been found.It was reported that those catalytic DNAs,especially 10 23 deoxyribozyme,could be used to cleave and suppress various mRNAs of pathogenic microbes,malignant tumors and some genetic diseases.Their structures,mechanisms of cleaving RNA,dynamic characteristics,current application were summarized;and the design principle,advantages of using as new gene therapeutic tools,possible application in future were discussed. |
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| Keywords: | catalytic DNA deoxyribozyme gene therapy drug design |
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