| 乌拉尔甘草中新香豆素的化学研究 |
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| 引用本文： | 王彩兰,张如意,韩永生,董熙嘏,刘文彬.乌拉尔甘草中新香豆素的化学研究[J].药学学报,1991,26(2):147-151. |
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| 作者姓名： | 王彩兰 张如意 韩永生 董熙嘏 刘文彬 |
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| 作者单位： | 河南师范大学化学系，北京医科大学药学院，河南师范大学化学系，河南师范大学化学系，河南师范大学化学系 新乡 453002，北京 100083，新乡 453002，新乡 453002，新乡 453002 |
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| 摘 要： | 甘草是一味重要的传统中药,为临床广泛使用。多年来国内外学者对其化学成分的研究颇为重视。近来,用不同溶剂对甘草进行分步提取,以酶和受体生物学指标进行监测,发现乌拉尔甘草(Glycyrrhiza uralensis Fisch)的二氯甲烷提取物对安定受体,胆囊收缩素受体以及二氢还原酶具有明显的抑制作用。为了寻找其中的有效成分,我们对该部分进行了化
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| 关 键 词： | 乌拉尔甘草 香豆素 新甘草酚 |
| 收稿时间： | 1989-06-19 |
CHEMICAL STUDIES OF COUMARINS FROM GLYCYRRHIZA URALENSlS FISCH |
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| CL Wang,RY Zhang,YS Han,XG Dong and WB Liu.CHEMICAL STUDIES OF COUMARINS FROM GLYCYRRHIZA URALENSlS FISCH[J].Acta Pharmaceutica Sinica,1991,26(2):147-151. |
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| Authors: | CL Wang RY Zhang YS Han XG Dong and WB Liu |
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| Institution: | Chemistry Department of Henan Normal University, Xinxiang. |
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| Abstract: | This paper reports the isolation and identification of eight crystalline substances (I, II, III, IV, V, VI, VII, VIII) from the root of Glycyrrhiza uralensis Fisch. Besides the known compounds liquiritin, hexacosance, beta-sitosterol, licoricone liquiritigenin and etc, a new constituent, named neoglycyrol was obtained by sillica gel and polyamide column chromatographic method. Its chemical structure was elucidated by means of chemical and spectrometric analysis (UV, IR, NMR and MS). Neoglycyrol, C21H18O6, yellow needles with mp 263.5-265 degrees C, possesses one methoxyl, one isopentenyl and two hydroxyls. Its diacetate derivative is C25H22O8 with mp 202-203.5 degrees C. Its dimethyl ether derivative is C23H22O6 with mp 207-208.5 degrees C. Its structure was found to be VII. |
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| Keywords: | Glycyrrhiza uralensis Fisch Coumarin Neoglycyrol |
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