沙利度胺联合小剂量HA方案治疗老年急性髓系白血病23例

目的:观察沙利度胺联合小剂量HA方案治疗老年人急性髓细胞白血病(AML)的疗效及安全性。方法:回顾分析接受沙利度胺联合小剂量HA方案治疗的老年AML患者23例的临床资料。沙利度胺100mg/d连续口服,小剂量HA方案为高三尖杉酯碱(har)1～2mg/d,静脉滴注,d1～14。阿糖胞苷(Ara-c)25～50mg/d静脉滴注,d1～14。14d为1疗程。1～2疗程结束后评价疗效。治疗1疗程达完全缓解者用常规DA、MA、EA等方案进行巩固治疗,连用2疗程不缓解者则更换方案。观察治疗效果及不良反应。结果:23例患者中,完全缓解7例,部分缓解9例,CR率30.4%,总有效率69.2%。所有患者均顺利完成化疗,不良反应除骨髓抑制外,无严重感染、出血及重要脏器损伤,无早期死亡病例。结论:沙利度胺联合小剂量HA方案治疗老年人AML疗效确切,相对安全,耐受性好。

Thalidomide combined with small dose of HA regimen in the treatment of elderly patients with acute myeloid leukemia:a report of 23 cases

Objective:Observation of thalidomide combined with smll dose of HA regimen in the treatment of elderly acute myeloid leukemia:efficacy and safety.Methods:Petrospective analysis of receiving thalidomide combined with small dose of HA regimen in the treatment of elderly patients with the clinical dada of 23 caces with aml.Thalidomide100mg/d continuous oral,small dose of HA scheme of homoharringtonine(har)1~2mg/d,intrayenou infusion,d1~14.cytosine arabinoside(Ara-c) 25~50mg/d intrayenous infusion,d1~14,14 days for1 courses.After the 1~2 treatment course evaluation of efficacy.1courses of treatment achieved complete remission with conventional DA、 MA、 EA plan of consolidation therapy,on 2 successive treatment dose not relieve the latter replacement programme,observation of treatment results and adverse reactions.Results:In 23 patients,complete remission in 7 cases,partial remission in 9 cases,CR rate 30.4%,total efficiency 69.2%.All patients were successfully completed chemotherapy,adverse reaction in bone marrow suppression,no serious infection,bleeding and important organ injuries,no early death cases.Conclusion:Thalidomide combined with small dose of HA regimen in the treatment of treatment of elderly AML curative effect is accurate,sate,well tolerated.