Photodynamic inhibition of infection caused by drug-resistant variants of herpes simplex virus type I |
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| Authors: | Kvacheva Z B Shukanova N A Votyakov V I Lobanok E S Vorobei A V Nikolaeva S N |
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| Affiliation: | (1) State Institute of Epidemiology and Microbiology, Ministry of Health of Belarus Republic, Belarus;(2) National Academy of Sciences of Belarus, Institute of Photobiology, Minsk |
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| Abstract: | Membranotropic amphiphilic chromophore merocyanine 540 sensitized photodynamic inhibition of drug-resistant and sensitive variants of type I herpes simplex virus in cultured Vero cell. Optimal conditions of photodamage to virus particles and infected cells were determined (merocyanine 540 concentration 1  M, illumination dose 32.5-65.0 kJ/m2, exposure at early stages of infection). Infected cells actively bind the photosensitizer, which explains their selective photodamage. |
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| Keywords: | herpes simplex virus Vero cell culture photodynamic exposure merocyanine 540 |
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