| bFGF、TGF-β联合使用对大鼠骨骼肌卫星细胞增殖能力的影响 |
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| 引用本文： | 黎炜英,朱卫雄,刘丹. bFGF、TGF-β联合使用对大鼠骨骼肌卫星细胞增殖能力的影响[J]. 武汉大学学报(医学版), 2007, 28(6): 733-736 |
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| 作者姓名： | 黎炜英 朱卫雄 刘丹 |
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| 作者单位： | 武汉大学期刊社,湖北,武汉,430072;武汉大学体育部,湖北,武汉,430072;成都中医药大学体育学院,四川,成都,611137 |
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| 摘 要： | 目的:探讨bFGF和TGF-β联合使用对体外培养大鼠骨骼肌卫星细胞增殖能力的影响。方法:采用组织学方法观察bFGF组、TGF-β组、bFGF+TGF-β组及对照组中体外培养的大鼠骨骼肌卫星细胞形态变化及细胞增殖状况。结果:bFGF和TGF-β单独作用对体外培养大鼠骨骼肌卫星细胞增殖作用较弱;两者联合作用,促增殖作用显著增强。结论:bFGF和TGF-β联合作用对体外培养骨骼肌卫星细胞的增殖起了重要作用。
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| 关 键 词： | 碱性成纤维生长因子 转化生长因子 骨骼肌卫星细胞 |
| 文章编号： | 1671-8852（2007）06-0733-04 |
| 修稿时间： | 2007-05-16 |
Combined Effect of bFGF and TGF-beta on the Proliferation of Rat Skeletal Muscle Satellite Cells in Vitro |
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| LI Weiyin,ZHU Weixiong,LIU Dan. Combined Effect of bFGF and TGF-beta on the Proliferation of Rat Skeletal Muscle Satellite Cells in Vitro[J]. Medical Journal of Wuhan University, 2007, 28(6): 733-736 |
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| Authors: | LI Weiyin ZHU Weixiong LIU Dan |
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| Affiliation: | 1Journals Press, 2Dept. of Physical Education, Wuhan University, Wuhan 430072, China;3School of Physical Education, Chengdu University of TCM, Chengdu 611137, China |
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| Abstract: | Objective: To investigate the combined effects of basic fibroblast growth factor (bFGF) and transforming growth factor-beta (TGF-β) on the proliferation of cultured rat skeletal muscle satellite cells in vitro. Methods: Histological method was used to detect the effect of bFGF and TGF-β on the cell proliferation of rat skeletal muscle satellite cells. Results: Single use of bFGF and TGF-β had only weak effect on the proliferation, while the combination of both had a significantly enhanced effect. Conclusion: The combination of bFGF and TGF-β might play a role in the proliferation and differentiation of rat skeletal muscle satellite cells in vitro. |
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| Keywords: | Basic Fibroblast Growth Factor Transforming Growth Factor-beta Skeletal Muscle Satellite Cells |
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