Western Blot analysis of immunoglobulin G antibodies to pneumococcal protein antigens in healthy adults |
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| Authors: | J. Renneberg M. Svinhufvud K. Prellner P. Christensen |
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| Affiliation: | (1) Department of Clinical Microbiology, Copenhagen University, Herlev General Hospital, Herlev, Denmark;(2) Department of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden;(3) Department of Clinical Microbiology, Lund University, Malmö General Hospital, Malmö, Sweden |
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| Abstract: | Using the Western Blot technique, sera from apparently healthy individuals were shown to contain antibodies against pneumococcal protein antigens of different molecular weights. A remarkable correlation was found to exist between the number of protein bands stained and the level of antibodies to type-specific carbohydrate antigens and C-polysaccharide. The findings suggest that the presence of antibodies against protein antigens reflects past infection with pneumococci. |
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