Compositional analysis of low quantities of phase separation in hot-melt-extruded solid dispersions: a combined atomic force microscopy, photothermal fourier-transform infrared microspectroscopy, and localised thermal analysis approach |
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| Authors: | Qi Sheng Belton Peter Nollenberger Kathrin Gryczke Andreas Craig Duncan Q M |
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| Institution: | (1) School of Pharmacy, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK;(2) School of Chemistry, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK;(3) Evonik R?hm GmbH, Kirschenallee, 64293 Darmstadt, Germany |
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| Abstract: | Purpose To characterise phase separations in aged hot-melt-extruded solid dispersions at a micron to submicron scale. |
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