抑郁症患者与正常人认知功能评估的比较

目的 探讨抑郁症患者与正常人认知功能的差异;探讨抑郁患者抑郁症状和认知功能的相关性.方法 对110例新近发作或两周内未服用抗抑郁药物的抑郁症患者和114例正常成人进行了认知功能的对照性评估;抑郁症患者治疗前后认知功能的改变进行评估.结果 患者组WCST的分类数、总错误数均明显高于对照组(分类数:8.35±0.7,P=0.00;总错误数:7.60±2.8,P=0.00),对照组的正确数和分类数明显高于患者组(40.40±2.8,P=0.00).患者组中HAMD总分与WCST的分类数呈正相关,与分类数、正确数呈负相关,治疗前后HAMD总分、WCST的总测验次数、持续错误数、随机错误数比较均有显著性差异(P＜0.01).结论 抑郁症患者存在认知功能损害,其认知功能损害与病情的严重程度有关,认知功能的降低可能提示病人额叶功能的缺损.

Correlation between Depression Symptom and Wisconsin Card Sorting Test in Patients with Depression

Objective The purpose of the study was to explore the differenceand correlation between clinical symptom and performances in Wisconsin Card Sorting Test ( WCST) in unmedicatcd patients with recent onset depression and normal controls.Methods one-hundre and ten un-medicatcd depression patients with recent onset and one-hundred and fourteen normal controls attended in this comparison assessment.They were studied with Wisconsin Card Sorting Test, and were assessed with HAMD-24. patients were retested after treated with an tidepressant for 8 weeks.Results Depressive patients significantly worse in cognitive tests than normal control on total trials, preservative errors, random errors of WCST (P<0.O1).and the normal did better on corrects and categories completes of WCST than the patients(P<0.01). Positive correlations were found between the total score of HAMD and the total errors of WCST (P<0.01). Significant negative correlations were found between that of HAMD and corrects and categories completes of WCST (P<0.05).In depression group, The result of follow up in 110 patients showed.they did better after treatment.Conclusion Depressive patients have cognitive dysfunction,which positively related to severity of depression ,which may mean their dysfunction on frontal lobe.