Synthesis and evaluation of biological and nonlinear optical properties of some novel 2,4-disubstituted [1,3]-thiazoles carrying 2-(aryloxymethyl)-phenyl moiety |
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Authors: | Channamata Shankar Naveena Boja Poojary Thangavelu Arulmoli Kumshi Manjunatha Ashwatanarayana Prabhu Nalilu Sucheta Kumari |
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Institution: | 1. Department of Chemistry, Mangalore University, Mangalagangothri, 575199, Karnataka, India 2. SeQuent Scientific Limited, New Mangalore, 575011, Karnataka, India 3. Department of Physics, M.I.T. Manipal University, Manipal, 576104, Karnataka, India 4. Department of Biochemistry, K. S. Hegde Medical Academy, Deralakatte, 574162, Karnataka, India
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Abstract: | A series of 2,4-disubstituted-1,3]-thiazoles (4a–p and 6a–l) was synthesized from 2-(aryloxymethyl)benzoic acids (1a–d) through a multistep reaction sequence in good yield. The structures of the new compounds were established on the basis of their elemental analyses, IR, 1H-NMR, 13C-NMR and mass spectral data. All the synthesized compounds were screened for their antimicrobial and anti-inflammatory activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial and anti-inflammatory agents. The nonlinear optical (NLO) property of 4a–p was also studied. The compound 4n with 2-(3-methylphenoxymethyl)phenyl and 4-nitrophenyl substituents showed very good NLO property compared to other compounds and also the reference compound, urea. |
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