止血敏磁控缓释微球在兔胃的靶向和止血功效

目的：对自行制备的止血敏磁控缓释微球（止血敏微球）进行兔胃靶向试验，观察其靶向和止血效力。方法：用x线摄影观察止血敏微球在兔胃的分布情况，用分光光度法检测靶区的止血敏含量，观察其在兔胃的止血功效。结果：止血敏微球能有效地准确定位于胃靶区，3．0g微球在磁场强度0．49T，梯度0．23T／cm状态下可产生28cm水柱的压力；胃靶区粘摸层止血敏含量检测结果：磁控组、非磁控组和静脉组的平均含量分别为1869ug/g,108ug/g,30ug/g；磁控组是非磁控组的17倍，是静脉组的62倍。经统计学分析，P＜0．01，存在特别显差异。微球可在10min内明显控制兔胃小动脉活动性出血，对照组则需30min以上。结论：止血敏磁控缓释微球有可能成为治疗上消化道大出血的理想药物和一些新的简便而有效的非手术疗法。

Efficacy of magnetically controlled ethamsylate microspheres in targeting normal and bleeding rabbit stomach

Objective To demonstrate the efficacy of magnetically controlled ethamsyiate microspheres in targeting normal and bleeding rabbit stomach. Methods X-ray photo, detecting ethamsyiate content in targeting site tissue and using die microspheres in treatment of rabbit stomach bleeding. Results 1) The signs of the ethamsyiate microspheres gathered and arranged along magnetic lines in normal rabbit stomach in shape of hill towards the poles could be seen clearly on X-ray photos.2) The average ethamsyiate concentration in target site tissue of the magnetically controlled group had demonstrated 17 fold increase than controlled group,62 fold increase than the injection group; P<0.01.3) The ethamsylate microshperes controlled by magnets could completely curb the active hemorrhage in rabbit stomach within 10 minutes. Conclusion These results suggested that the ethamsyiate microspheres be apparently superior to injectio or oral ethamsyiate in treatment of upper gastrointestinal hemorrhage.