| 一级并行米氏消除药物的稳态特性与给药方法 |
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| 引用本文： | 刘定远 林晓军. 一级并行米氏消除药物的稳态特性与给药方法[J]. 华西药学杂志, 1995, 10(2): 81-86 |
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| 作者姓名： | 刘定远 林晓军 |
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| 作者单位： | 华西医科大学数学教研室，卫生部成都生物制品研究所 |
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| 摘 要： | 对非线性过程按一级并行米氏消除的药物，先给出ｎ次静脉推注药物浓度的解析表达式；然后进一步研究多剂给药的稳态特性，给出了稳态药物浓度、最高坪水平、最低坪水平、平均稳态浓度、达坪分数和积累系数等的解析表达式；并讨论了它们在制定最佳用药方案中的应用。
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| 关 键 词： | 给药法 药物代谢动力学 稳态特性 米氏方程 |
STEADY-STATE CHARACTERISTICS AND DOSAGE ADMINISTRATION OF DRUGS FOR PARALLEL FIRST ORDER AND MICHAELIS-MENTEN ELIMINATION |
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| Liu Dingyuan. STEADY-STATE CHARACTERISTICS AND DOSAGE ADMINISTRATION OF DRUGS FOR PARALLEL FIRST ORDER AND MICHAELIS-MENTEN ELIMINATION[J]. West China Journal of Pharmaceutical Sciences, 1995, 10(2): 81-86 |
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| Authors: | Liu Dingyuan |
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| Abstract: | In nonlinear process of the parallel first order and michaehs-menten elimination drugs,the analytical expression of the drug concentration after n times intravenous injection was given. The steady-statecharacteristics of multiple intravenous dosing was studied and the analytical expressions about the steady-state drug concentration,the maximum,minimum and average drug concentration and accumulation coefficient were given.Then their application in making the optimal dosage regimen was discussed. |
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| Keywords: | Parallel first order and michaelis-menten elimination prosisses Maximum plateau level Steady-stale characteristics Steady-state concentration Accumulation coefficient |
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