阴性精神分裂症认知功能改善与HVA和5-HIAA的关系

目的：探讨阴性精神分裂症认知功能的改善与ＨＶＡ和５－ＨＩＡＡ变化的关系。方法：对１３例阴性精神分裂症在氯氮平治疗前和治疗８周后分别采用韦氏成人记忆量表（ＷＭＳ），数字划消测验和威期康星卡片分类测验（Ｗｉｓｃｏｎｓｉｎ ｃａｒｄ ｓｏｒｔｉｎｇ ｔｅｓｔ，ＷＣＳＴ）评估其记忆、注意及执行功能，采用高效液相色谱－电化学检测测定其治疗前和治疗后脑脊液中ＤＡ代谢产物高香草酸（ＨＶＡ）和５－ＨＴ代谢产物五羟

A study on the relationship of negative schizophrenia cognitive function improvement with HVA and 5-HIAA.

Objective:To explore the relationship of negative schizophrenic cognitive function improvement with HVA and 5 HIAA. Method:Thirteen negative schizophrenic patients were treated with clozapine for 8 weeks.Memory,attention,executive function were assessed separately with Waise memory scale (WMS),cancellation test (CT) and Wisconsin card sorting test (WCST) before and after treatment,and cerebrospinal fluid (CSF) HVA and 5 HIAA levels were determined with HPLC ECD. Results:Part of short memory was improving with decreasing of HVA or increasing of 5 HIAA,while significant correlation were not found between improvement of memory quotient (MQ),attention,executive function and change of HVA,5 HIAA. Conclusion:The great part of negative schizophrenic cognitive function improvement has marked correlation with change of DA and 5 HT.