| TRAIL受体在膀胱癌中的表达及意义 |
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| 引用本文： | 张志超,张智清,张强,张立国,曾革非,郭应禄.TRAIL受体在膀胱癌中的表达及意义[J].中华泌尿外科杂志,2001,22(10):616-618. |
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| 作者姓名： | 张志超 张智清 张强 张立国 曾革非 郭应禄 |
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| 作者单位： | 北京大学第一医院北京大学泌尿外科研究所 |
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| 摘 要： | 目的：了解肿瘤坏死因子相关诱导凋亡配体（TRAIL）受体在膀胱癌组织中的表达及意义。方法：采用RT－PCR及Northern blot方法检测TRAIL受体在膀胱癌组织及正常膀胱粘膜中的表达。结果：死亡受体DR4、DR5在膀胱癌组织及正常膀胱粘膜中呈强表达，候受体DcR-1在正常膀胱粘膜呈强表达，假受体DcR-2未见表达。结论：TRAIL基因在膀胱移行上皮细胞癌凋亡机制中可能发挥重要作用。
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| 关 键 词： | 膀胱肿瘤 癌 肿瘤坏死因子相关诱导凋亡配体受体 |
| 修稿时间： | 2000年10月25 |
Expression of tumor necrosis factor-related apoptosis-induce ligand receptors in bladder transitional cell cancer |
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| ZHANG Zhichao,ZHANG Zhiqing,ZHANG Qiang,et al..Expression of tumor necrosis factor-related apoptosis-induce ligand receptors in bladder transitional cell cancer[J].Chinese Journal of Urology,2001,22(10):616-618. |
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| Authors: | ZHANG Zhichao ZHANG Zhiqing ZHANG Qiang |
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| Institution: | ZHANG Zhichao,ZHANG Zhiqing,ZHANG Qiang,et al.Department of Urology,the First Hospital,Institute of Urology,Peking University,Beijing 100034,China |
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| Abstract: | Objective To investigate the expression of tumor necrosis factor-related apoptosis-induce ligand (TRAIL) receptors in bla dder transitional cell cancer. Methods TRAIL receptors m RNA were tested by means of RT-PCR and Northern Blot in bladder transitional ce ll cancer tissue. Results The expression of death recept or 4 (DR4) and death receptor 5 (DR5) have been certificated in bladder transiti onal cell cancer and normal bladder tissue,decoy receptor 1 (DcR1) expressed onl y in normal bladder tissue. Conclusions TRAIL gene may p lay an important role in the apoptosis of bladder transitional cell cancer. |
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| Keywords: | Bladder neoplasms Carcinoma Tumor necro sis factor-related apoptosis-induce ligand (TRAIL) recptors |
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