进行期银屑病患者活性氧代谢变化探讨

目的：探讨进行期银屑病患者活性氧代谢变化。方法：采用细胞化学发光分析技术测定患者及健康对照组外周血淋巴细胞化学发光强度（ Ｌｙｃｌ）及多形核白细胞化学发光强度（ Ｐ Ｍ Ｎｃｌ），同时测定血浆超氧化物歧化酶（ Ｓ Ｏ Ｄ）、全血谷胱甘肽过氧化物酶（ Ｇ Ｓ Ｈ Ｐｘ）以及血浆丙二醛（ Ｍ Ｄ Ａ）含量。结果：银屑病患者 Ｌｙｃｌ及 Ｐ Ｍ Ｎｃｌ较对照组显著增强（ Ｐ＜ ０．０５），血浆 Ｓ Ｏ Ｄ活力明显增强（ Ｐ＜ ０．０５）， Ｍ Ｄ Ａ 浓度较对照组明显增高（ Ｐ＜ ００５）。全血 Ｇ Ｓ Ｈ Ｐｘ 活力较对照组显著下降（ Ｐ＜ ０．０５）。结论：进行期银屑病患者细胞功能改变，机体活性氧代谢增强，抗氧化功能下降，组织细胞损伤加快。活性氧损伤可能是该病患者皮损炎症的重要原因。

studiesonthe Metabo1ic Change of Reactive Oxygen Spedes in Patients with Psoriasis

Objectiv: To investigate the metabolic changes of reactive oxygen species in patients with psoriasis. Methods: The changes of chemoiluminescence intensity of lymphocytes (Ly cl) and polymorphonuclear leukocytes (PMN cl) in peripheral bolld were studied by the cellular chemoiluminescence method. The serum superoxide dismutase (SOD). blood glutathione peroxidase (GSH Px) and serum malondialdehyde (MDA) were also determined respectively. Results: The Ly cl and PNM cl of patients with psoriasis significantly increased compared with normal group (P<0.05). The serum SOD nad MDA also increased (P<0.05) and the blood GSH Px decreased compared with normal group (P<0.05). Conclusion: The results showed that the cellular immunity and the antioxidant system of patients with psoriasis were damaged. So we concluded that the reactive oxygen species has an important role in skin's injury reaction in patients with psoriasis.